Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50365505 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_807677 (CHEMBL1959442) |
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IC50 | 100±n/a nM |
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Citation | Hirata, Y; Hirata, M; Kawaratani, Y; Shibano, M; Taniguchi, M; Yasuda, M; Ohmomo, Y; Nagaoka, Y; Baba, K; Uesato, S Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain. Bioorg Med Chem Lett22:1926-30 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50365505 |
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n/a |
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Name | BDBM50365505 |
Synonyms: | CHEMBL1957464 |
Type | Small organic molecule |
Emp. Form. | C23H24N4O3S |
Mol. Mass. | 436.527 |
SMILES | Nc1ccc(cc1NC(=O)c1ccc(CNC(=O)N2CCOCC2)cc1)-c1cccs1 |
Structure |
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