| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50365570 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_808016 (CHEMBL1961075) |
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| IC50 | 0.17±n/a nM |
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| Citation |  Lacombe, P; Arbour, M; Aspiotis, R; Cauchon, E; Chen, A; Dubé, D; Falgueyret, JP; Fournier, PA; Gallant, M; Grimm, E; Han, Y; Juteau, H; Liu, S; Mellon, C; Ramtohul, Y; Simard, D; St-Jacques, R; Tsui, GC 3,4-Diarylpiperidines as potent renin inhibitors. Bioorg Med Chem Lett22:1953-7 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50365570 |
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| n/a |
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| Name | BDBM50365570 |
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| Synonyms: | CHEMBL1957788 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30F2N2O2 |
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| Mol. Mass. | 476.5575 |
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| SMILES | CC(=O)NCCc1ccccc1-c1ccc([C@H]2CNCC[C@@]22OCc3cc(F)c(F)cc23)c(C)c1 |r| |
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| Structure | 
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