| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil collagenase |
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| Ligand | BDBM50366173 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_805645 (CHEMBL1960479) |
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| IC50 | 400±n/a nM |
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| Citation |  Topai, A; Breccia, P; Minissi, F; Padova, A; Marini, S; Cerbara, I In silico scaffold evaluation and solid phase approach to identify new gelatinase inhibitors. Bioorg Med Chem20:2323-37 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil collagenase |
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| Name: | Neutrophil collagenase |
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| Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
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| Type: | Enzyme |
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| Mol. Mass.: | 53413.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22894 |
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| Residue: | 467 |
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| Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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| BDBM50366173 |
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| n/a |
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| Name | BDBM50366173 |
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| Synonyms: | CHEMBL1957604 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N2O5S2 |
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| Mol. Mass. | 380.439 |
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| SMILES | ONC(=O)[C@@H]1CS(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| |
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| Structure | 
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