Compile Data Set for Download or QSAR

Found 94 hits with Last Name = 'padova' and Initial = 'a'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50026872 (CHEMBL1233506 | SC-74020) Show SMILES CCCCCc1ccc(cc1)C(=O)Nc1ccc(cc1)S(=O)(=O)N(CCN1CCOCC1)[C@H](C(C)C)C(=O)NO |r| Show InChI InChI=1S/C29H42N4O6S/c1-4-5-6-7-23-8-10-24(11-9-23)28(34)30-25-12-14-26(15-13-25)40(37,38)33(27(22(2)3)29(35)31-36)17-16-32-18-20-39-21-19-32/h8-15,22,27,36H,4-7,16-21H2,1-3H3,(H,30,34)(H,31,35)/t27-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50366175 (CHEMBL1957606) Show SMILES ONC(=O)[C@@H]1CS(=O)(=O)CN1S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C16H15ClN2O7S2/c17-11-1-3-12(4-2-11)26-13-5-7-14(8-6-13)28(24,25)19-10-27(22,23)9-15(19)16(20)18-21/h1-8,15,21H,9-10H2,(H,18,20)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366175 (CHEMBL1957606) Show SMILES ONC(=O)[C@@H]1CS(=O)(=O)CN1S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C16H15ClN2O7S2/c17-11-1-3-12(4-2-11)26-13-5-7-14(8-6-13)28(24,25)19-10-27(22,23)9-15(19)16(20)18-21/h1-8,15,21H,9-10H2,(H,18,20)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50366203 (CHEMBL1957601) Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)N2CSC[C@H]2C(=O)NO)cc1 |r| Show InChI InChI=1S/C17H18N2O6S2/c1-24-12-2-4-13(5-3-12)25-14-6-8-15(9-7-14)27(22,23)19-11-26-10-16(19)17(20)18-21/h2-9,16,21H,10-11H2,1H3,(H,18,20)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50366175 (CHEMBL1957606) Show SMILES ONC(=O)[C@@H]1CS(=O)(=O)CN1S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C16H15ClN2O7S2/c17-11-1-3-12(4-2-11)26-13-5-7-14(8-6-13)28(24,25)19-10-27(22,23)9-15(19)16(20)18-21/h1-8,15,21H,9-10H2,(H,18,20)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP8 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50366205 (CHEMBL1957603) Show SMILES ONC(=O)[C@@H]1CSCN1S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1 |r| Show InChI InChI=1S/C16H15FN2O5S2/c17-11-1-3-12(4-2-11)24-13-5-7-14(8-6-13)26(22,23)19-10-25-9-15(19)16(20)18-21/h1-8,15,21H,9-10H2,(H,18,20)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50366175 (CHEMBL1957606) Show SMILES ONC(=O)[C@@H]1CS(=O)(=O)CN1S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C16H15ClN2O7S2/c17-11-1-3-12(4-2-11)26-13-5-7-14(8-6-13)28(24,25)19-10-27(22,23)9-15(19)16(20)18-21/h1-8,15,21H,9-10H2,(H,18,20)/t15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP14 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured a...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366173 (CHEMBL1957604) Show SMILES ONC(=O)[C@@H]1CS(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O5S2/c19-16(17-20)15-10-24(21)11-18(15)25(22,23)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-,24?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366203 (CHEMBL1957601) Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)N2CSC[C@H]2C(=O)NO)cc1 |r| Show InChI InChI=1S/C17H18N2O6S2/c1-24-12-2-4-13(5-3-12)25-14-6-8-15(9-7-14)27(22,23)19-11-26-10-16(19)17(20)18-21/h2-9,16,21H,10-11H2,1H3,(H,18,20)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366205 (CHEMBL1957603) Show SMILES ONC(=O)[C@@H]1CSCN1S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1 |r| Show InChI InChI=1S/C16H15FN2O5S2/c17-11-1-3-12(4-2-11)24-13-5-7-14(8-6-13)26(22,23)19-10-25-9-15(19)16(20)18-21/h1-8,15,21H,9-10H2,(H,18,20)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366204 (CHEMBL1957602) Show SMILES ONC(=O)[C@@H]1CSCN1S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C16H15ClN2O5S2/c17-11-1-3-12(4-2-11)24-13-5-7-14(8-6-13)26(22,23)19-10-25-9-15(19)16(20)18-21/h1-8,15,21H,9-10H2,(H,18,20)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50366204 (CHEMBL1957602) Show SMILES ONC(=O)[C@@H]1CSCN1S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C16H15ClN2O5S2/c17-11-1-3-12(4-2-11)24-13-5-7-14(8-6-13)26(22,23)19-10-25-9-15(19)16(20)18-21/h1-8,15,21H,9-10H2,(H,18,20)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50366175 (CHEMBL1957606) Show SMILES ONC(=O)[C@@H]1CS(=O)(=O)CN1S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C16H15ClN2O7S2/c17-11-1-3-12(4-2-11)26-13-5-7-14(8-6-13)28(24,25)19-10-27(22,23)9-15(19)16(20)18-21/h1-8,15,21H,9-10H2,(H,18,20)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP12 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured a...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366174 (CHEMBL1957605) Show SMILES ONC(=O)[C@@H]1CS(=O)(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O6S2/c19-16(17-20)15-10-25(21,22)11-18(15)26(23,24)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM13344 (N-[4-Chloro-3-(3-pyridinyloxymethyl)phenyl]-3-fluo...) Show SMILES Fc1cc(cc(c1)C(=O)Nc1ccc(Cl)c(COc2cccnc2)c1)N1CCOCC1 Show InChI InChI=1S/C23H21ClFN3O3/c24-22-4-3-19(11-17(22)15-31-21-2-1-5-26-14-21)27-23(29)16-10-18(25)13-20(12-16)28-6-8-30-9-7-28/h1-5,10-14H,6-9,15H2,(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents	MMDB PDB Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	7.4	22
Astex					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 48: 414-26 (2005) Article DOI: 10.1021/jm049575n BindingDB Entry DOI: 10.7270/Q26M352S
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neutrophil collagenase (Homo sapiens (Human))	BDBM50366174 (CHEMBL1957605) Show SMILES ONC(=O)[C@@H]1CS(=O)(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O6S2/c19-16(17-20)15-10-25(21,22)11-18(15)26(23,24)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP8 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50366204 (CHEMBL1957602) Show SMILES ONC(=O)[C@@H]1CSCN1S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C16H15ClN2O5S2/c17-11-1-3-12(4-2-11)24-13-5-7-14(8-6-13)26(22,23)19-10-25-9-15(19)16(20)18-21/h1-8,15,21H,9-10H2,(H,18,20)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP3 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50366173 (CHEMBL1957604) Show SMILES ONC(=O)[C@@H]1CS(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O5S2/c19-16(17-20)15-10-24(21)11-18(15)25(22,23)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-,24?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP14 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured a...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM13354 (3-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-1-(4-chl...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Cl)cc2)n(n1)-c1ccccc1 Show InChI InChI=1S/C20H21ClN4O/c1-20(2,3)17-13-18(25(24-17)16-7-5-4-6-8-16)23-19(26)22-15-11-9-14(21)10-12-15/h4-13H,1-3H3,(H2,22,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	196	n/a	n/a	n/a	n/a	7.4	22
Astex					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 48: 414-26 (2005) Article DOI: 10.1021/jm049575n BindingDB Entry DOI: 10.7270/Q26M352S
					More data for this Ligand-Target Pair				3D Structure (crystal)
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366200 (CHEMBL1957598) Show SMILES ONC(=O)[C@@H]1CSCN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O4S2/c19-16(17-20)15-10-23-11-18(15)24(21,22)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50366200 (CHEMBL1957598) Show SMILES ONC(=O)[C@@H]1CSCN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O4S2/c19-16(17-20)15-10-23-11-18(15)24(21,22)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM13336 (4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...) Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	7.4	22
Astex					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 48: 414-26 (2005) Article DOI: 10.1021/jm049575n BindingDB Entry DOI: 10.7270/Q26M352S
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM13353 (3-fluoro-5-(morpholin-4-yl)-N-{1-[2-(pyridin-4-yl)...) Show SMILES Fc1cc(cc(c1)C(=O)Nc1ccc2ccn(CCc3ccncc3)c2c1)N1CCOCC1 Show InChI InChI=1S/C26H25FN4O2/c27-22-15-21(16-24(17-22)30-11-13-33-14-12-30)26(32)29-23-2-1-20-6-10-31(25(20)18-23)9-5-19-3-7-28-8-4-19/h1-4,6-8,10,15-18H,5,9,11-14H2,(H,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Patents	DrugBank MMDB PDB Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	7.4	22
Astex					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 48: 414-26 (2005) Article DOI: 10.1021/jm049575n BindingDB Entry DOI: 10.7270/Q26M352S
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM13345 (1-(5-tert-Butyl-2H-pyrazol-3-yl)-3-[4-chloro-3-(py...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Cl)c(COc3cccnc3)c2)[nH]n1 Show InChI InChI=1S/C20H22ClN5O2/c1-20(2,3)17-10-18(26-25-17)24-19(27)23-14-6-7-16(21)13(9-14)12-28-15-5-4-8-22-11-15/h4-11H,12H2,1-3H3,(H3,23,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Patents	DrugBank MMDB PDB Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	7.4	22
Astex					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 48: 414-26 (2005) Article DOI: 10.1021/jm049575n BindingDB Entry DOI: 10.7270/Q26M352S
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neutrophil collagenase (Homo sapiens (Human))	BDBM50366173 (CHEMBL1957604) Show SMILES ONC(=O)[C@@H]1CS(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O5S2/c19-16(17-20)15-10-24(21)11-18(15)25(22,23)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-,24?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP8 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50366174 (CHEMBL1957605) Show SMILES ONC(=O)[C@@H]1CS(=O)(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O6S2/c19-16(17-20)15-10-25(21,22)11-18(15)26(23,24)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50366174 (CHEMBL1957605) Show SMILES ONC(=O)[C@@H]1CS(=O)(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O6S2/c19-16(17-20)15-10-25(21,22)11-18(15)26(23,24)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP12 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured a...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50366202 (CHEMBL1957600) Show SMILES ONC(=O)[C@@H]1CSCN1S(=O)(=O)c1cccc2cccnc12 |r| Show InChI InChI=1S/C13H13N3O4S2/c17-13(15-18)10-7-21-8-16(10)22(19,20)11-5-1-3-9-4-2-6-14-12(9)11/h1-6,10,18H,7-8H2,(H,15,17)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50366173 (CHEMBL1957604) Show SMILES ONC(=O)[C@@H]1CS(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O5S2/c19-16(17-20)15-10-24(21)11-18(15)25(22,23)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-,24?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM13351 (3-fluoro-5-(morpholin-4-yl)-N-{3-[2-(pyridin-4-yl)...) Show SMILES Fc1cc(cc(c1)C(=O)Nc1ccc2[nH]cc(CCc3ccncc3)c2c1)N1CCOCC1 Show InChI InChI=1S/C26H25FN4O2/c27-21-13-20(14-23(15-21)31-9-11-33-12-10-31)26(32)30-22-3-4-25-24(16-22)19(17-29-25)2-1-18-5-7-28-8-6-18/h3-8,13-17,29H,1-2,9-12H2,(H,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Patents	DrugBank MMDB PDB Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	7.4	22
Astex					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 48: 414-26 (2005) Article DOI: 10.1021/jm049575n BindingDB Entry DOI: 10.7270/Q26M352S
					More data for this Ligand-Target Pair				3D Structure (crystal)
Stromelysin-1 (Homo sapiens (Human))	BDBM50366205 (CHEMBL1957603) Show SMILES ONC(=O)[C@@H]1CSCN1S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1 |r| Show InChI InChI=1S/C16H15FN2O5S2/c17-11-1-3-12(4-2-11)24-13-5-7-14(8-6-13)26(22,23)19-10-25-9-15(19)16(20)18-21/h1-8,15,21H,9-10H2,(H,18,20)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP3 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366202 (CHEMBL1957600) Show SMILES ONC(=O)[C@@H]1CSCN1S(=O)(=O)c1cccc2cccnc12 |r| Show InChI InChI=1S/C13H13N3O4S2/c17-13(15-18)10-7-21-8-16(10)22(19,20)11-5-1-3-9-4-2-6-14-12(9)11/h1-6,10,18H,7-8H2,(H,15,17)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50366204 (CHEMBL1957602) Show SMILES ONC(=O)[C@@H]1CSCN1S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C16H15ClN2O5S2/c17-11-1-3-12(4-2-11)24-13-5-7-14(8-6-13)26(22,23)19-10-25-9-15(19)16(20)18-21/h1-8,15,21H,9-10H2,(H,18,20)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP1 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM13349 (2-({4-[2-(1H-indol-3-yl)ethyl]pyrimidin-2-yl}amino...) Show SMILES CC(C)(CO)Nc1nccc(CCc2c[nH]c3ccccc23)n1 Show InChI InChI=1S/C18H22N4O/c1-18(2,12-23)22-17-19-10-9-14(21-17)8-7-13-11-20-16-6-4-3-5-15(13)16/h3-6,9-11,20,23H,7-8,12H2,1-2H3,(H,19,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	7.4	22
Astex					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 48: 414-26 (2005) Article DOI: 10.1021/jm049575n BindingDB Entry DOI: 10.7270/Q26M352S
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366198 (CHEMBL1957596) Show SMILES ONC(=O)[C@@H]1CCC(=O)N1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C17H16N2O5S/c20-16-11-10-15(17(21)18-22)19(16)25(23,24)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,22H,10-11H2,(H,18,21)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50366198 (CHEMBL1957596) Show SMILES ONC(=O)[C@@H]1CCC(=O)N1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C17H16N2O5S/c20-16-11-10-15(17(21)18-22)19(16)25(23,24)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,22H,10-11H2,(H,18,21)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50366173 (CHEMBL1957604) Show SMILES ONC(=O)[C@@H]1CS(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O5S2/c19-16(17-20)15-10-24(21)11-18(15)25(22,23)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-,24?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP3 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50366174 (CHEMBL1957605) Show SMILES ONC(=O)[C@@H]1CS(=O)(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O6S2/c19-16(17-20)15-10-25(21,22)11-18(15)26(23,24)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP1 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50366173 (CHEMBL1957604) Show SMILES ONC(=O)[C@@H]1CS(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O5S2/c19-16(17-20)15-10-24(21)11-18(15)25(22,23)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-,24?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP12 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured a...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366176 (CHEMBL1957575) Show SMILES ONC(=O)[C@H]1CCC(=O)N1Cc1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C18H18N2O3/c21-17-11-10-16(18(22)19-23)20(17)12-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,16,23H,10-12H2,(H,19,22)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50366174 (CHEMBL1957605) Show SMILES ONC(=O)[C@@H]1CS(=O)(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O6S2/c19-16(17-20)15-10-25(21,22)11-18(15)26(23,24)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP14 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured a...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366199 (CHEMBL1957597) Show SMILES ONC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C17H18N2O4S/c20-17(18-21)16-7-4-12-19(16)24(22,23)15-10-8-14(9-11-15)13-5-2-1-3-6-13/h1-3,5-6,8-11,16,21H,4,7,12H2,(H,18,20)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50366174 (CHEMBL1957605) Show SMILES ONC(=O)[C@@H]1CS(=O)(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O6S2/c19-16(17-20)15-10-25(21,22)11-18(15)26(23,24)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP3 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50366173 (CHEMBL1957604) Show SMILES ONC(=O)[C@@H]1CS(=O)CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C16H16N2O5S2/c19-16(17-20)15-10-24(21)11-18(15)25(22,23)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-,24?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP1 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366197 (CHEMBL1957595) Show SMILES ONC(=O)[C@@H]1CSC(=O)N1Cc1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C17H16N2O3S/c20-16(18-22)15-11-23-17(21)19(15)10-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-9,15,22H,10-11H2,(H,18,20)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366185 (CHEMBL1957584) Show SMILES ONC(=O)[C@@H]1CCC(=O)N1Cc1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C18H18N2O3/c21-17-11-10-16(18(22)19-23)20(17)12-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,16,23H,10-12H2,(H,19,22)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM13342 (2-({5-[(2,6-dichlorophenyl)methoxy]pyridin-2-yl}am...) Show SMILES CC(C)(CO)Nc1ccc(OCc2c(Cl)cccc2Cl)cn1 Show InChI InChI=1S/C16H18Cl2N2O2/c1-16(2,10-21)20-15-7-6-11(8-19-15)22-9-12-13(17)4-3-5-14(12)18/h3-8,21H,9-10H2,1-2H3,(H,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	7.4	22
Astex					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 48: 414-26 (2005) Article DOI: 10.1021/jm049575n BindingDB Entry DOI: 10.7270/Q26M352S
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50366176 (CHEMBL1957575) Show SMILES ONC(=O)[C@H]1CCC(=O)N1Cc1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C18H18N2O3/c21-17-11-10-16(18(22)19-23)20(17)12-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,16,23H,10-12H2,(H,19,22)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM13343 (N-[4-Chloro-3-(3-pyridinyloxymethyl)phenyl]benzami...) Show SMILES Clc1ccc(NC(=O)c2ccccc2)cc1COc1cccnc1 Show InChI InChI=1S/C19H15ClN2O2/c20-18-9-8-16(22-19(23)14-5-2-1-3-6-14)11-15(18)13-24-17-7-4-10-21-12-17/h1-12H,13H2,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	7.4	22
Astex					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 48: 414-26 (2005) Article DOI: 10.1021/jm049575n BindingDB Entry DOI: 10.7270/Q26M352S
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50366201 (CHEMBL1957599) Show SMILES ONC(=O)[C@@H]1CSCN1S(=O)(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C14H14N2O4S2/c17-14(15-18)13-8-21-9-16(13)22(19,20)12-6-5-10-3-1-2-4-11(10)7-12/h1-7,13,18H,8-9H2,(H,15,17)/t13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl) Curated by ChEMBL					Assay Description Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...				Bioorg Med Chem 20: 2323-37 (2012) Article DOI: 10.1016/j.bmc.2012.02.010 BindingDB Entry DOI: 10.7270/Q2N29XD5
					More data for this Ligand-Target Pair

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