Ki Summary

Reaction Details

Report a problem with these data

Target

Platelet-activating factor receptor

Ligand

BDBM50004633

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_155000

IC50

13±n/a nM

Citation

Hodgkin, EE; Miller, A; Whittaker, M A partial pharmacophore for the platelet activating factor (PAF) receptor Bioorg Med Chem Lett2:597-602 (1992) Article

More Info.:

Get all data from this article, Assay Method

Platelet-activating factor receptor

Name:

Platelet-activating factor receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

39219.60

Organism:

Homo sapiens (Human)

Description:

PAF Platelet activating factor PTAFR HUMAN::P25105

Residue:

342

Sequence:

MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT
MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT
RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG
SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV
FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN

BDBM50004633

n/a

Name

BDBM50004633

Synonyms:

(S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester | 4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester | 4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-nicotinic acid ethyl ester | CHEMBL29067 | UK-74505

Type

Small organic molecule

Emp. Form.

C34H29ClN6O3

Mol. Mass.

605.085

SMILES

CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7|

Structure