Reaction Details |
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Target | Endothelin-converting enzyme 1 |
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Ligand | BDBM50287431 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_64340 |
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IC50 | 120±n/a nM |
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Citation | McKittrick, BA; Stamford, AW; Xiaoyu, Weng; Ke, Ma; Chackalamannil, S; Czarniecki, M; Cleven, R; Fawzi, AB Design and synthesis of phosphinic acids that triply inhibit endothelin converting enzyme, angiotensin converting enzyme and neutral endopeptidase 24.11 Bioorg Med Chem Lett6:1629-1634 (1996) Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-converting enzyme 1 |
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Name: | Endothelin-converting enzyme 1 |
Synonyms: | ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1) |
Type: | Enzyme |
Mol. Mass.: | 87155.11 |
Organism: | Homo sapiens (Human) |
Description: | P42892 |
Residue: | 770 |
Sequence: | MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
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BDBM50287431 |
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n/a |
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Name | BDBM50287431 |
Synonyms: | (S)-2-({1-[((R)-1-Benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-cyclopentanecarbonyl}-amino)-3-(4-hydroxy-phenyl)-propionic acid | CHEMBL42284 |
Type | Small organic molecule |
Emp. Form. | C32H37N2O8P |
Mol. Mass. | 608.6185 |
SMILES | OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)C1(CP(O)(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)CCCC1 |
Structure |
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