| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 3 |
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| Ligand | BDBM50071159 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_106374 |
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| IC50 | 8580±n/a nM |
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| Citation |  Valli, MJ; Schoepp, DD; Wright, RA; Johnson, BG; Kingston, AE; Tomlinson, R; Monn, JA Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid. Bioorg Med Chem Lett8:1985-90 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 3 |
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| Name: | Metabotropic glutamate receptor 3 |
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| Synonyms: | GPRC1C | GRM3 | GRM3_HUMAN | MGLUR3 | metabotropic glutamate 3 | metabotropic glutamate 3/1a | metabotropic glutamate 3/1c |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 98889.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | metabotropic glutamate 1c 0 HUMAN::Q14832 |
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| Residue: | 879 |
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| Sequence: | MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS
DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY
LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK
HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA
EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH
LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
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| BDBM50071159 |
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| n/a |
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| Name | BDBM50071159 |
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| Synonyms: | (2R,4R)-4-Amino-1-naphthalen-1-ylmethyl-pyrrolidine-2,4-dicarboxylic acid | CHEMBL302411 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N2O4 |
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| Mol. Mass. | 314.3358 |
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| SMILES | N[C@@]1(C[C@@H](N(Cc2cccc3ccccc23)C1)C(O)=O)C(O)=O |
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| Structure | 
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