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TargetNMBR
LigandBDBM50071738
Substrate/Competitorn/a
Meas. Tech.ChEBML_39622
Ki 0.620000±n/a nM
Citation Ashwood VBrownhill VHigginbottom MHorwell DCHughes JLewthwaite RAMcKnight ATPinnock RDPritchard MCSuman-Chauhan NWebb CWilliams SC PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist. Bioorg Med Chem Lett 8:2589-94 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
NMBR
Name:Neuromedin B receptor
Synonyms:Bombesin 1 | NMB-R | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:43447.11
Organism:Homo sapiens (Human)
Description:Bombesin 1 NMBR 0::P28336
Residue:390
Sequence:
MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLG
NIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIP
VIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAV
FSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLI
KSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSL
GHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAV
RMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
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  Blast E-value cutoff:
BDBM50071738
n/a
NameBDBM50071738
Synonyms:(S)-N-[1-(4-Hydroxy-phenyl)-cyclohexylmethyl]-3-(1H-indol-3-yl)-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-propionamide | CHEMBL87846
TypeSmall organic molecule
Emp. Form.C32H35N5O5
Mol. Mass.569.6508
SMILESC[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(cc1)[N+]([O-])=O)C(=O)NCC1(CCCCC1)c1ccc(O)cc1
Structure
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