Reaction Details |
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Target | Gastrin-releasing peptide receptor |
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Ligand | BDBM50071744 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_39763 |
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Ki | 0.700000±n/a nM |
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Citation | Ashwood, V; Brownhill, V; Higginbottom, M; Horwell, DC; Hughes, J; Lewthwaite, RA; McKnight, AT; Pinnock, RD; Pritchard, MC; Suman-Chauhan, N; Webb, C; Williams, SC PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist. Bioorg Med Chem Lett8:2589-94 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Gastrin-releasing peptide receptor |
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Name: | Gastrin-releasing peptide receptor |
Synonyms: | Bombesin 2 | GRP-R | GRP-preferring bombesin receptor | GRPR | GRPR_HUMAN | Gastrin releasing peptide receptor | Gastrin-releasing peptide receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 43214.53 |
Organism: | Homo sapiens (Human) |
Description: | Bombesin 2 GRPR 0::P30550 |
Residue: | 384 |
Sequence: | MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNIT
LIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQ
LTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSD
LHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQS
AYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLH
FVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTS
LKSTNPSVATFSLINGNICHERYV
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BDBM50071744 |
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n/a |
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Name | BDBM50071744 |
Synonyms: | AcBB(7-14) | CHEMBL314375 |
Type | Small organic molecule |
Emp. Form. | C45H67N13O10S |
Mol. Mass. | 982.16 |
SMILES | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(C)C)C(N)=O |
Structure |
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