| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src |
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| Ligand | BDBM50080177 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_202591 (CHEMBL806415) |
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| IC50 | 6000±n/a nM |
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| Citation |  Buchanan, JL; Bohacek, RS; Luke, GP; Hatada, M; Lu, X; Dalgarno, DC; Narula, SS; Yuan, R; Holt, DA Structure-based design and synthesis of a novel class of Src SH2 inhibitors. Bioorg Med Chem Lett9:2353-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase Src |
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| Name: | Proto-oncogene tyrosine-protein kinase Src |
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| Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src |
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| Type: | Protein |
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| Mol. Mass.: | 59838.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P12931 |
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| Residue: | 536 |
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| Sequence: | MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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| BDBM50080177 |
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| n/a |
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| Name | BDBM50080177 |
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| Synonyms: | (S)-4-{(S)-2-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-carboxy-butyrylamino}-4-((1S,2S)-1-carbamoyl-2-methyl-butylcarbamoyl)-butyric acid | Ac-pY-E-E-I-NH2 | CHEMBL311937 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H40N5O13P |
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| Mol. Mass. | 673.606 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(N)=O |
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| Structure | 
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