| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain-1 catalytic subunit |
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| Ligand | BDBM50080208 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_43488 (CHEMBL657761) |
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| Ki | 56000±n/a nM |
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| Citation |  Peet, NP; Kim, HO; Marquart, AL; Angelastro, MR; Nieduzak, TR; White, JN; Friedrich, D; Flynn, GA; Webster, ME; Vaz, RJ; Linnik, MD; Koehl, JR; Mehdi, S; Bey, P; Emary, B; Hwang, KK Hydroxyoxazolidines as alpha-aminoacetaldehye equivalents: novel inhibitors of calpain. Bioorg Med Chem Lett9:2365-70 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Calpain-1 catalytic subunit |
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| Name: | Calpain-1 catalytic subunit |
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| Synonyms: | CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1 |
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| Type: | Protein |
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| Mol. Mass.: | 81880.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 714 |
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| Sequence: | MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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| BDBM50080208 |
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| n/a |
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| Name | BDBM50080208 |
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| Synonyms: | CHEMBL73869 | [(R)-1-((2R,3S)-3-Benzyl-2-hydroxy-morpholine-4-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30N2O5 |
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| Mol. Mass. | 426.5054 |
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| SMILES | CC(C)[C@@H](NC(=O)OCc1ccccc1)C(=O)N1CCO[C@@H](O)[C@@H]1Cc1ccccc1 |
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| Structure | 
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