| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor X |
|---|
| Ligand | BDBM50081007 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_48479 |
|---|
| Ki | 370±n/a nM |
|---|
| Citation |  Choi-Sledeski, YM; Becker, MR; Green, DM; Davis, R; Ewing, WR; Mason, HJ; Ly, C; Spada, A; Liang, G; Cheney, D; Barton, J; Chu, V; Brown, K; Colussi, D; Bentley, R; Leadley, R; Dunwiddie, C; Pauls, HW Aminoisoquinolines: design and synthesis of an orally active benzamidine isostere for the inhibition of factor XA. Bioorg Med Chem Lett9:2539-44 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor X |
|---|
| Name: | Coagulation factor X |
|---|
| Synonyms: | Coagulation factor X | F10 | FA10_BOVIN | Factor Xa (fXa) |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 54498.45 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_1364435 |
|---|
| Residue: | 492 |
|---|
| Sequence: | MAGLLHLVLLSTALGGLLRPAGSVFLPRDQAHRVLQRARRANSFLEEVKQGNLERECLEE
ACSLEEAREVFEDAEQTDEFWSKYKDGDQCEGHPCLNQGHCKDGIGDYTCTCAEGFEGKN
CEFSTREICSLDNGGCDQFCREERSEVRCSCAHGYVLGDDSKSCVSTERFPCGKFTQGRS
RRWAIHTSEDALDASELEHYDPADLSPTESSLDLLGLNRTEPSAGEDGSQVVRIVGGRDC
AEGECPWQALLVNEENEGFCGGTILNEFYVLTAAHCLHQAKRFTVRVGDRNTEQEEGNEM
AHEVEMTVKHSRFVKETYDFDIAVLRLKTPIRFRRNVAPACLPEKDWAEATLMTQKTGIV
SGFGRTHEKGRLSSTLKMLEVPYVDRSTCKLSSSFTITPNMFCAGYDTQPEDACQGDSGG
PHVTRFKDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIDKIMKARAGAAGSRGHSEA
PATWTVPPPLPL
|
|
|
|---|
| BDBM50081007 |
|---|
| n/a |
|---|
| Name | BDBM50081007 |
|---|
| Synonyms: | 7-Methoxy-naphthalene-2-sulfonic acid [1-(2-amino-quinolin-7-ylmethyl)-2-oxo-pyrrolidin-3-yl]-amide | CHEMBL419490 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H24N4O4S |
|---|
| Mol. Mass. | 476.547 |
|---|
| SMILES | COc1ccc2ccc(cc2c1)S(=O)(=O)NC1CCN(Cc2ccc3ccc(N)nc3c2)C1=O |
|---|
| Structure | 
|
|---|
Search and Browse
