| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM13279 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_48479 |
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| Ki | 7±n/a nM |
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| Citation |  Choi-Sledeski, YM; Becker, MR; Green, DM; Davis, R; Ewing, WR; Mason, HJ; Ly, C; Spada, A; Liang, G; Cheney, D; Barton, J; Chu, V; Brown, K; Colussi, D; Bentley, R; Leadley, R; Dunwiddie, C; Pauls, HW Aminoisoquinolines: design and synthesis of an orally active benzamidine isostere for the inhibition of factor XA. Bioorg Med Chem Lett9:2539-44 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Coagulation factor X | F10 | FA10_BOVIN | Factor Xa (fXa) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54498.45 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_1364435 |
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| Residue: | 492 |
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| Sequence: | MAGLLHLVLLSTALGGLLRPAGSVFLPRDQAHRVLQRARRANSFLEEVKQGNLERECLEE
ACSLEEAREVFEDAEQTDEFWSKYKDGDQCEGHPCLNQGHCKDGIGDYTCTCAEGFEGKN
CEFSTREICSLDNGGCDQFCREERSEVRCSCAHGYVLGDDSKSCVSTERFPCGKFTQGRS
RRWAIHTSEDALDASELEHYDPADLSPTESSLDLLGLNRTEPSAGEDGSQVVRIVGGRDC
AEGECPWQALLVNEENEGFCGGTILNEFYVLTAAHCLHQAKRFTVRVGDRNTEQEEGNEM
AHEVEMTVKHSRFVKETYDFDIAVLRLKTPIRFRRNVAPACLPEKDWAEATLMTQKTGIV
SGFGRTHEKGRLSSTLKMLEVPYVDRSTCKLSSSFTITPNMFCAGYDTQPEDACQGDSGG
PHVTRFKDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIDKIMKARAGAAGSRGHSEA
PATWTVPPPLPL
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| BDBM13279 |
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| n/a |
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| Name | BDBM13279 |
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| Synonyms: | 4-{[(3S)-3-[(7-methoxynaphthalene-2-)(methyl)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}thiophene-2-carboximidamide | 4-{[(3S)-3-{[(7-methoxynaphthalen-2-yl)sulfonyl](methyl)amino}-2-oxopyrrolidin-1-yl]methyl}thiophene-2-carboximidamide | CHEMBL84638 | RPR120844 | Sulfonamidopyrrolidinone |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N4O4S2 |
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| Mol. Mass. | 472.58 |
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| SMILES | COc1ccc2ccc(cc2c1)S(=O)(=O)N(C)[C@H]1CCN(Cc2csc(c2)C(N)=N)C1=O |r| |
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| Structure | 
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