| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine--tRNA ligase, cytoplasmic |
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| Ligand | BDBM50091496 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_211026 |
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| IC50 | 21±n/a nM |
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| Citation |  Berge, JM; Copley, RC; Eggleston, DS; Hamprecht, DW; Jarvest, RL; Mensah, LM; O'Hanlon, PJ; Pope, AJ Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383. Bioorg Med Chem Lett10:1811-4 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine--tRNA ligase, cytoplasmic |
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| Name: | Tyrosine--tRNA ligase, cytoplasmic |
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| Synonyms: | SYYC_HUMAN | Tyrosyl-tRNA synthetase | YARS | YARS1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59145.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_211030 |
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| Residue: | 528 |
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| Sequence: | MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIA
DFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKG
TDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVD
AQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKED
VKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFA
AEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEP
EEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLV
VVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEE
LKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
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| BDBM50091496 |
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| n/a |
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| Name | BDBM50091496 |
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| Synonyms: | (R)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-((2S,3S,4S,5S)-1,3,4,5-tetrahydroxy-piperidin-2-yl)-acetic acid | CHEMBL52779 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H23N3O8 |
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| Mol. Mass. | 385.3691 |
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| SMILES | N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]([C@H]1[C@H](O)[C@@H](O)[C@@H](O)CN1O)C(O)=O |
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| Structure | 
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