Reaction Details | |||
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Target | Mu-type opioid receptor | ||
Ligand | BDBM50087690 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_149009 | ||
Ki | 1.5±n/a nM | ||
Citation | Röver, S; Wichmann, J; Jenck, F; Adam, G; Cesura, AM ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones. Bioorg Med Chem Lett10:831-4 (2000) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Mu-type opioid receptor | |||
Name: | Mu-type opioid receptor | ||
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 44503.11 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. | ||
Residue: | 398 | ||
Sequence: |
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BDBM50087690 | |||
n/a | |||
Name | BDBM50087690 | ||
Synonyms: | 8-Bicyclohexyl-4-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one | CHEMBL354065 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H37N3O | ||
Mol. Mass. | 395.5808 | ||
SMILES | O=C1NCN(c2ccccc2)C11CCN(CC1)[C@@H]1CC[C@@H](CC1)C1CCCCC1 |wU:17.19,20.26,(14.26,-1.31,;14.73,-2.76,;16.19,-3.25,;16.19,-4.79,;14.72,-5.26,;14.26,-6.7,;12.74,-7.03,;12.27,-8.49,;13.3,-9.64,;14.8,-9.32,;15.28,-7.85,;13.82,-4.01,;13.07,-2.67,;11.53,-2.68,;10.76,-4.02,;11.53,-5.34,;13.07,-5.34,;9.22,-4.02,;8.45,-2.69,;6.91,-2.69,;6.14,-4.02,;6.91,-5.35,;8.47,-5.35,;4.6,-4.01,;3.85,-5.35,;2.29,-5.34,;1.54,-4,;2.31,-2.67,;3.85,-2.68,)| | ||
Structure |