| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vasopressin V1a receptor |
|---|
| Ligand | BDBM50147230 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_214405 |
|---|
| IC50 | 7±n/a nM |
|---|
| Citation |  Xiang, MA; Chen, RH; Demarest, KT; Gunnet, J; Look, R; Hageman, W; Murray, WV; Combs, DW; Rybczynski, PJ; Patel, M Synthesis and evaluation of nonpeptide substituted spirobenzazepines as potent vasopressin antagonists. Bioorg Med Chem Lett14:3143-6 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vasopressin V1a receptor |
|---|
| Name: | Vasopressin V1a receptor |
|---|
| Synonyms: | AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor |
|---|
| Type: | Receptor |
|---|
| Mol. Mass.: | 46820.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P37288 |
|---|
| Residue: | 418 |
|---|
| Sequence: | MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAV
TFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGP
DWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFV
LSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFIC
YNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAY
IVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCV
QSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
|
|
|
|---|
| BDBM50147230 |
|---|
| n/a |
|---|
| Name | BDBM50147230 |
|---|
| Synonyms: | CHEMBL319636 | methyl 2-[1-[4-(5-fluoro-2-methylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3-ylcarboxamido]acetate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H32FN3O5 |
|---|
| Mol. Mass. | 569.6227 |
|---|
| SMILES | COC(=O)CNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3C)cc1)c1ccccc1C2 |t:8| |
|---|
| Structure | 
|
|---|
Search and Browse
