| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain-1 catalytic subunit |
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| Ligand | BDBM50140548 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_43499 |
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| IC50 | 120±n/a nM |
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| Citation |  Wang, Y; Huang, JC; Zhou, ZL; Yang, W; Guastella, J; Drewe, J; Cai, SX Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid. Bioorg Med Chem Lett14:1269-72 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calpain-1 catalytic subunit |
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| Name: | Calpain-1 catalytic subunit |
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| Synonyms: | CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1 |
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| Type: | Protein |
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| Mol. Mass.: | 81880.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 714 |
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| Sequence: | MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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| BDBM50140548 |
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| n/a |
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| Name | BDBM50140548 |
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| Synonyms: | 3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-5-fluoro-4-oxo-pentanoic acid methyl ester | CHEMBL23453 | acs.jmedchem.1c00409_ST.196 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25FN2O6 |
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| Mol. Mass. | 396.41 |
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| SMILES | COC(=O)CC(NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)CF |
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| Structure | 
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