| Reaction Details |
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 | Report a problem with these data |
| Target | Neprilysin |
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| Ligand | BDBM50027513 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_64504 |
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| IC50 | 11000±n/a nM |
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| Citation |  Fournié-Zaluski, MC; Chaillet, P; Soroca-Lucas, E; Marçais-Collado, H; Costentin, J; Roques, BP New carboxyalkyl inhibitors of brain enkephalinase: synthesis, biological activity, and analgesic properties. J Med Chem26:60-5 (1983) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neprilysin |
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| Name: | Neprilysin |
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| Synonyms: | Mme | NEP_MOUSE |
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| Type: | PROTEIN |
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| Mol. Mass.: | 85694.36 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_144448 |
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| Residue: | 750 |
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| Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASVEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLKLLPDIYGWPVASDNWDQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQSLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEVNGKSFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYREDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
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| BDBM50027513 |
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| n/a |
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| Name | BDBM50027513 |
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| Synonyms: | 2-[2-(2-Carboxy-ethylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C18H24N2O5 |
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| Mol. Mass. | 348.3947 |
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| SMILES | CC(C)CC(NC(=O)C(Cc1ccccc1)NCCC([O-])=O)C([O-])=O |
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| Structure | 
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