| Reaction Details |
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 | Report a problem with these data |
| Target | S-adenosylmethionine synthase isoform type-1/type-2 |
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| Ligand | BDBM50118232 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_104961 (CHEMBL878217) |
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| Ki | 110000±n/a nM |
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| Citation |  Kappler, F; Hai, TT; Hampton, A Isozyme-specific enzyme inhibitors. 10. Adenosine 5'-triphosphate derivatives as substrates or inhibitors of methionine adenosyltransferases of rat normal and hepatoma tissues. J Med Chem29:318-22 (1986) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| S-adenosylmethionine synthase isoform type-1/type-2 |
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| Name: | S-adenosylmethionine synthase isoform type-1/type-2 |
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| Synonyms: | S-adenosylmethionine synthetase (MAT 1 and MAT 2) |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 104961 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | S-adenosylmethionine synthase isoform type-1 |
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| Synonyms: | AdoMet synthetase 1 | Ams1 | MAT 1 | MAT-I/III | METK1_RAT | Mat1a | Methionine adenosyltransferase 1 | Methionine adenosyltransferase I/III | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase alpha and beta forms | S-adenosylmethionine synthetase isoform type-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43692.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_11027 |
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| Residue: | 397 |
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| Sequence: | MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETV
CKTGMVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQ
CVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPD
SKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDED
TIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAAR
WVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERDELLEVVNKNFDLRPG
VIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
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| Component 2 |
| Name: | S-adenosylmethionine synthase isoform type-2 |
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| Synonyms: | AdoMet synthetase 2 | Ams2 | MAT 2 | MAT-II | METK2_RAT | Mat2a | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II | S-Adenosylmethionine Synthase (AdoMet) | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase gamma form | S-adenosylmethionine synthetase isoform type-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43713.68 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_105118 |
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| Residue: | 395 |
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| Sequence: | MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
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| BDBM50118232 |
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| n/a |
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| Name | BDBM50118232 |
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| Synonyms: | 2-MeSATP | ATP, 2-meS | CHEMBL336208 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H18N5O13P3S |
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| Mol. Mass. | 553.273 |
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| SMILES | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1 |
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| Structure | 
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