Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50011885 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_54441 |
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IC50 | 72±n/a nM |
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Citation | Rosowsky, A; Freisheim, JH; Moran, RG; Solan, VC; Bader, H; Wright, JE; Radike-Smith, M Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain. J Med Chem29:655-60 (1986) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_MOUSE | Dhfr |
Type: | Enzyme |
Mol. Mass.: | 21608.82 |
Organism: | Mus musculus (Mouse) |
Description: | n/a |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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BDBM50011885 |
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n/a |
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Name | BDBM50011885 |
Synonyms: | 5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanoic acid | CHEMBL280864 |
Type | Small organic molecule |
Emp. Form. | C19H23N9O3 |
Mol. Mass. | 425.4444 |
SMILES | NCCCC(NC(=O)c1ccc(NCc2cnc3nc(N)nc(N)c3n2)cc1)C(O)=O |
Structure |
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