| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50011886 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54441 |
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| IC50 | 160±n/a nM |
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| Citation |  Rosowsky, A; Freisheim, JH; Moran, RG; Solan, VC; Bader, H; Wright, JE; Radike-Smith, M Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain. J Med Chem29:655-60 (1986) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_MOUSE | Dhfr |
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| Type: | Enzyme |
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| Mol. Mass.: | 21608.82 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
|
|
|
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| BDBM50011886 |
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| n/a |
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| Name | BDBM50011886 |
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| Synonyms: | 5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoic acid | CHEMBL36083 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25N9O3 |
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| Mol. Mass. | 439.471 |
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| SMILES | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCCN)C(O)=O |
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| Structure | 
|
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