| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane-A synthase |
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| Ligand | BDBM50024934 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_210118 |
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| IC50 | 3±n/a nM |
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| Citation |  Wright, WB; Tomcufcik, AS; Chan, PS; Marsico, JW; Press, JB Thromboxane synthetase inhibitors and antihypertensive agents. 4. N-[(1H-imidazol-1-yl)alkyl] derivatives of quinazoline-2,4(1H,3H)-diones, quinazolin-4(3H)-ones, and 1,2,3-benzotriazin-4(3H)-ones. J Med Chem30:2277-83 (1988) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane-A synthase |
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| Name: | Thromboxane-A synthase |
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| Synonyms: | Cyp5 | Cyp5a1 | Cytochrome P450 5A1 | THAS_RAT | TXA synthase | TXS | Tbxas1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59971.80 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_209768 |
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| Residue: | 533 |
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| Sequence: | MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFR
QGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLI
ADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQR
CYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLA
RILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMV
TEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATH
PECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEV
LGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCL
GVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
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| BDBM50024934 |
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| n/a |
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| Name | BDBM50024934 |
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| Synonyms: | 7-Chloro-3-(3-imidazol-1-yl-2-methyl-propyl)-1H-quinazoline-2,4-dione; hydrochloride | CHEMBL544065 | CHEMBL76234 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15ClN4O2 |
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| Mol. Mass. | 318.758 |
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| SMILES | CC(Cn1ccnc1)Cn1c(=O)[nH]c2cc(Cl)ccc2c1=O |
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| Structure | 
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