Reaction Details |
| Report a problem with these data |
Target | Neprilysin |
---|
Ligand | BDBM50020155 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_144760 (CHEMBL752824) |
---|
IC50 | 945±n/a nM |
---|
Citation | Hernandez, JF; Soleilhac, JM; Roques, BP; Fournié-Zaluski, MC Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. J Med Chem31:1825-31 (1988) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Neprilysin |
---|
Name: | Neprilysin |
Synonyms: | Atriopeptidase | CD10 antigen | CD_antigen=CD10 | Enkephalinase | MME | NEP | NEP_RABIT | Neutral Endopeptidase | Neutral endopeptidase 24.11 |
Type: | Enzyme |
Mol. Mass.: | 85570.75 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | NEP was purified to homogeneity from rabbit kidney. |
Residue: | 750 |
Sequence: | MGRSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTVIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCVNETAIDSRGGQPLLKLLPDVYGWPVATQNWEQTYGT
SWSAEKSIAQLNSNYGKKVLINFFVGTDDKNSMNHIIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMIAVAKLIRQEEGLPIDENQISVEMNKVMELEKEIANATTKSEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWSNFTNEIMSTVNINIPNEEDVVVYAPEYLIKLKPILT
KYFPRDFQNLFSWRFIMDLVSSLSRTYKDSRNAFRKALYGTTSESATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWITGAA
IVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGIDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GSLQNSVEFSEAFQCPKNSYMNPEKKCRVW
|
|
|
BDBM50020155 |
---|
n/a |
---|
Name | BDBM50020155 |
Synonyms: | CHEMBL299588 | N-(1-Hydroxycarbamoyl-2-phenyl-ethyl)-2-methyl-malonamic acid(RR+RS) | N-(1-Hydroxycarbamoyl-2-phenyl-ethyl)-2-methyl-malonamic acid(SR+SS) |
Type | Small organic molecule |
Emp. Form. | C13H16N2O5 |
Mol. Mass. | 280.2765 |
SMILES | CC(C(O)=O)C(=O)NC(Cc1ccccc1)C(=O)NO |
Structure |
|