| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50452588 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_45241 (CHEMBL658944) |
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| Ki | 16±n/a nM |
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| Citation |  Baldwin, JJ; Ponticello, GS; Anderson, PS; Christy, ME; Murcko, MA; Randall, WC; Schwam, H; Sugrue, MF; Springer, JP; Gautheron, P Thienothiopyran-2-sulfonamides: novel topically active carbonic anhydrase inhibitors for the treatment of glaucoma. J Med Chem32:2510-3 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50452588 |
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| n/a |
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| Name | BDBM50452588 |
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| Synonyms: | CHEMBL2092885 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H15ClN2O4S3 |
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| Mol. Mass. | 346.874 |
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| SMILES | Cl.CCN[C@@H]1CCS(=O)(=O)c2sc(cc12)S(N)(=O)=O |r| |
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| Structure | 
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