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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Carbonic anhydrase 2 | ||
| Ligand | BDBM50017727 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_45241 | ||
| Ki | 6.8±n/a nM | ||
| Citation |  Baldwin, JJ; Ponticello, GS; Anderson, PS; Christy, ME; Murcko, MA; Randall, WC; Schwam, H; Sugrue, MF; Springer, JP; Gautheron, P Thienothiopyran-2-sulfonamides: novel topically active carbonic anhydrase inhibitors for the treatment of glaucoma. J Med Chem32:2510-3 (1989) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Carbonic anhydrase 2 | |||
| Name: | Carbonic anhydrase 2 | ||
| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 29250.71 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00918 | ||
| Residue: | 260 | ||
| Sequence: |
| ||
| BDBM50017727 | |||
| n/a | |||
| Name | BDBM50017727 | ||
| Synonyms: | (R) 4-Hydroxy-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide | (R)-4-Hydroxy-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide | (S) 4-Hydroxy-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide | (S)-4-Hydroxy-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide | 4-Hydroxy-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide | CHEMBL314569 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C7H9NO5S3 | ||
| Mol. Mass. | 283.345 | ||
| SMILES | NS(=O)(=O)c1cc2C(O)CCS(=O)(=O)c2s1 | ||
| Structure | 
| ||