| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
|---|
| Ligand | BDBM34168 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_80668 |
|---|
| IC50 | 27±n/a nM |
|---|
| Citation |  Sit, SY; Parker, RA; Motoc, I; Han, W; Balasubramanian, N; Catt, JD; Brown, PJ; Harte, WE; Thompson, MD; Wright, JJ Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. J Med Chem33:2982-99 (1990) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
|---|
| Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
|---|
| Synonyms: | HMDH_RAT | HMG-CoA reductase | Hmgcr |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 96689.85 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Isolated rat liver microsomes were used as enzyme source. |
|---|
| Residue: | 887 |
|---|
| Sequence: | MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAEQSKVSLGLAEDVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVT
PKKAQDNCCRREPLLVRRNQKLSSVEEDPGVNQDRKVEVIKPLVAEAETSGRATFVLGAS
AASPPLALGAQEPGIELPSEPRPNEECLQILESAEKGAKFLSDAEIIQLVNAKHIPAYKL
ETLMETHERGVSIRRQLLSAKLAEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVA
GPLCLDGKEYQVPMATTEGCLVASTNRGCRAISLGGGASSRVLADGMSRGPVVRLPRACD
SAEVKSWLETPEGFAVVKEAFDSTSRFARLQKLHVTLAGRNLYIRLQSKTGDAMGMNMIS
KGTEKALLKLQEFFPELQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVL
KTTTEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLM
EASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARI
VCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQGTCTKKAA
|
|
|
|---|
| BDBM34168 |
|---|
| n/a |
|---|
| Name | BDBM34168 |
|---|
| Synonyms: | LOVASTATIN | MLS000069585 | SMR000058779 | US9115116, lovastatin | US9353061, Lovastatina | cid_53232 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H36O5 |
|---|
| Mol. Mass. | 404.5396 |
|---|
| SMILES | CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 |c:13,t:11| |
|---|
| Structure | 
|
|---|
Search and Browse
