Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 1A

Ligand

BDBM50011247

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1326 (CHEMBL616952)

4.1±n/a nM

Citation

Mellin, C; Vallgårda, J; Nelson, DL; Björk, L; Yu, H; Andén, NE; Csöregh, I; Arvidsson, LE; Hacksell, U A 3-D model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin. J Med Chem34:497-510 (1991) [PubMed]

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1A

Name:

5-hydroxytryptamine receptor 1A

Synonyms:

5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

46445.29

Organism:

Rattus norvegicus (rat)

Description:

Binding assays were performed using rat hippocampal membranes.

Residue:

422

Sequence:

MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR

BDBM50011247

n/a

Name

BDBM50011247

Synonyms:

7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol; hydrobromide | CHEMBL41436 | CHEMBL541621 | S-(-)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol

Type

Small organic molecule

Emp. Form.

C16H25NO

Mol. Mass.

247.3758

SMILES

CCCN(CCC)[C@H]1CCc2cccc(O)c2C1

Structure