| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50011702 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_195927 (CHEMBL803396) |
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| pH | 7.4±n/a |
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| IC50 | 2.5±n/a nM |
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| Comments | extracted |
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| Citation |  Williams, PD; Perlow, DS; Payne, LS; Holloway, MK; Siegl, PK; Schorn, TW; Lynch, RJ; Doyle, JJ; Strouse, JF; Vlasuk, GP Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics. J Med Chem34:887-900 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50011702 |
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| n/a |
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| Name | BDBM50011702 |
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| Synonyms: | CHEMBL169870 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy-2-(1-methyl-2-oxo-5-vinyl-pyrrolidin-3-yl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C36H52N6O6 |
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| Mol. Mass. | 664.8347 |
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| SMILES | CN1[C@H](C[C@@H]([C@H](O)[C@H](CC2CCCCC2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C1=O)C=C |
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| Structure | 
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