| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet-activating factor receptor |
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| Ligand | BDBM50004643 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_162882 |
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| IC50 | 13±n/a nM |
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| Citation |  Cooper, K; Fray, MJ; Parry, MJ; Richardson, K; Steele, J 1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives. J Med Chem35:3115-29 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet-activating factor receptor |
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| Name: | Platelet-activating factor receptor |
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| Synonyms: | PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor |
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| Type: | Protein |
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| Mol. Mass.: | 39005.63 |
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| Organism: | Cavia porcellus |
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| Description: | n/a |
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| Residue: | 342 |
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| Sequence: | MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLT
VADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVK
YPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKG
SKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAV
FVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
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| BDBM50004643 |
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| n/a |
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| Name | BDBM50004643 |
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| Synonyms: | 2-Chloro-6'-methyl-2'-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5'-(pyridin-2-ylcarbamoyl)-1',4'-dihydro-[3,4']bipyridinyl-3'-carboxylic acid ethyl ester (0.5 H2O) | CHEMBL106800 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H28ClN7O3 |
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| Mol. Mass. | 606.074 |
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| SMILES | CCOC(=O)C1=C(N=C(C)C(C1c1cccnc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| |
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| Structure | 
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