Found 144 hits with Last Name = 'richardson' and Initial = 'k' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50033212
(7,8-Dichloro-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1Cc2cc(Cl)c(Cl)cc2NC(=O)C1 Show InChI InChI=1S/C23H18Cl2N4O/c1-13-27-21-12-26-7-6-22(21)29(13)17-4-2-14(3-5-17)15-8-16-9-18(24)19(25)11-20(16)28-23(30)10-15/h2-7,9,11-12,15H,8,10H2,1H3,(H,28,30) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets. |
J Med Chem 38: 3514-23 (1995)
BindingDB Entry DOI: 10.7270/Q2PK0GSS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50033213
(7,8-Dichloro-1-methyl-4-[4-(2-methyl-imidazo[4,5-c...)Show SMILES CN1c2cc(Cl)c(Cl)cc2CC(CC1=O)c1ccc(cc1)-n1c(C)nc2cnccc12 Show InChI InChI=1S/C24H20Cl2N4O/c1-14-28-21-13-27-8-7-22(21)30(14)18-5-3-15(4-6-18)16-9-17-10-19(25)20(26)12-23(17)29(2)24(31)11-16/h3-8,10,12-13,16H,9,11H2,1-2H3 | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets. |
J Med Chem 38: 3514-23 (1995)
BindingDB Entry DOI: 10.7270/Q2PK0GSS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004622
(4-(2-Chloro-phenyl)-2-methyl-6-[4-(2-methyl-imidaz...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)OCCOC)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C32H31ClN4O5/c1-5-41-32(39)29-28(23-8-6-7-9-24(23)33)27(31(38)42-17-16-40-4)19(2)35-30(29)21-10-12-22(13-11-21)37-20(3)36-25-18-34-15-14-26(25)37/h6-15,18,27-28H,5,16-17H2,1-4H3 | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50033211
(7,8-Dichloro-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(Cl)c(Cl)cc2NC(=S)C1 |t:19| Show InChI InChI=1S/C22H15Cl2N5S/c1-12-26-20-11-25-7-6-21(20)29(12)14-4-2-13(3-5-14)17-10-22(30)28-19-9-16(24)15(23)8-18(19)27-17/h2-9,11H,10H2,1H3,(H,28,30) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets. |
J Med Chem 38: 3514-23 (1995)
BindingDB Entry DOI: 10.7270/Q2PK0GSS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50033223
(7,8-Dimethyl-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(C)c(C)cc2NC(=S)C1 |t:19| Show InChI InChI=1S/C24H21N5S/c1-14-10-20-21(11-15(14)2)28-24(30)12-19(27-20)17-4-6-18(7-5-17)29-16(3)26-22-13-25-9-8-23(22)29/h4-11,13H,12H2,1-3H3,(H,28,30) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets. |
J Med Chem 38: 3514-23 (1995)
BindingDB Entry DOI: 10.7270/Q2PK0GSS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50033214
(7,8-Dimethyl-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(C)c(C)cc2NC(=O)C1 |t:19| Show InChI InChI=1S/C24H21N5O/c1-14-10-20-21(11-15(14)2)28-24(30)12-19(27-20)17-4-6-18(7-5-17)29-16(3)26-22-13-25-9-8-23(22)29/h4-11,13H,12H2,1-3H3,(H,28,30) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets. |
J Med Chem 38: 3514-23 (1995)
BindingDB Entry DOI: 10.7270/Q2PK0GSS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50033206
(7,8-Dichloro-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(Cl)c(Cl)cc2NC(=O)C1 |t:19| Show InChI InChI=1S/C22H15Cl2N5O/c1-12-26-20-11-25-7-6-21(20)29(12)14-4-2-13(3-5-14)17-10-22(30)28-19-9-16(24)15(23)8-18(19)27-17/h2-9,11H,10H2,1H3,(H,28,30) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets. |
J Med Chem 38: 3514-23 (1995)
BindingDB Entry DOI: 10.7270/Q2PK0GSS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004615
(4-(2-Chloro-phenyl)-2-methyl-6-[4-(2-methyl-imidaz...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)OC(C)(C)C)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C33H33ClN4O4/c1-7-41-31(39)29-28(23-10-8-9-11-24(23)34)27(32(40)42-33(4,5)6)19(2)36-30(29)21-12-14-22(15-13-21)38-20(3)37-25-18-35-17-16-26(25)38/h8-18,27-28H,7H2,1-6H3 | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004630
(4-(2-Chloro-phenyl)-2-methyl-6-[4-(2-methyl-imidaz...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)OC)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C30H27ClN4O4/c1-5-39-30(37)27-26(21-8-6-7-9-22(21)31)25(29(36)38-4)17(2)33-28(27)19-10-12-20(13-11-19)35-18(3)34-23-16-32-15-14-24(23)35/h6-16,25-26H,5H2,1-4H3 | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004617
(4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-pyridi...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-c1cccnc1C |t:5,7| Show InChI InChI=1S/C33H29ClN4O3/c1-4-41-33(40)30-29(25-10-5-6-12-26(25)34)28(32(39)38-27-13-7-8-18-36-27)21(3)37-31(30)23-16-14-22(15-17-23)24-11-9-19-35-20(24)2/h5-19,28-29H,4H2,1-3H3,(H,36,38,39) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50033207
(7,8-Dimethyl-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(C)c(C)cc2N=C(N)C1 |t:19,30| Show InChI InChI=1S/C24H22N6/c1-14-10-20-21(11-15(14)2)29-24(25)12-19(28-20)17-4-6-18(7-5-17)30-16(3)27-22-13-26-9-8-23(22)30/h4-11,13H,12H2,1-3H3,(H2,25,29) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets. |
J Med Chem 38: 3514-23 (1995)
BindingDB Entry DOI: 10.7270/Q2PK0GSS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50004633
((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C34H29ClN6O3/c1-4-44-34(43)31-30(24-9-5-6-10-25(24)35)29(33(42)40-28-11-7-8-17-37-28)20(2)38-32(31)22-12-14-23(15-13-22)41-21(3)39-26-19-36-18-16-27(26)41/h5-19,29-30H,4H2,1-3H3,(H,37,40,42) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004637
(4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-imidaz...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-c1c(C)nc2ccccn12 |t:5,7| Show InChI InChI=1S/C35H30ClN5O3/c1-4-44-35(43)31-30(25-11-5-6-12-26(25)36)29(34(42)40-27-13-7-9-19-37-27)21(2)39-32(31)23-15-17-24(18-16-23)33-22(3)38-28-14-8-10-20-41(28)33/h5-20,29-30H,4H2,1-3H3,(H,37,40,42) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286206
((R)-5-tert-Butylcarbamoyl-4-(2-chloro-phenyl)-6-me...)Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc3ccccc23)N=C(C)C([C@H]1c1ccccc1Cl)C(=O)NC(C)(C)C |c:5,t:23| Show InChI InChI=1S/C31H37ClN4O4/c1-7-40-30(38)28-24(18-39-17-16-36-20(3)34-23-14-10-11-15-25(23)36)33-19(2)26(29(37)35-31(4,5)6)27(28)21-12-8-9-13-22(21)32/h8-15,26-27H,7,16-18H2,1-6H3,(H,35,37)/t26?,27-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004650
(6-Methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1OC(F)(F)F)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C35H29F3N6O4/c1-4-47-34(46)31-30(24-9-5-6-10-27(24)48-35(36,37)38)29(33(45)43-28-11-7-8-17-40-28)20(2)41-32(31)22-12-14-23(15-13-22)44-21(3)42-25-19-39-18-16-26(25)44/h5-19,29-30H,4H2,1-3H3,(H,40,43,45) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004616
(4-(2-Chloro-phenyl)-2-methyl-6-[4-(2-methyl-imidaz...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)OCc1ccccc1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C36H31ClN4O4/c1-4-44-36(43)33-32(27-12-8-9-13-28(27)37)31(35(42)45-21-24-10-6-5-7-11-24)22(2)39-34(33)25-14-16-26(17-15-25)41-23(3)40-29-20-38-19-18-30(29)41/h5-20,31-32H,4,21H2,1-3H3 | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286203
(4-(2-Chloro-phenyl)-6-methyl-2-[2-(2-methyl-benzoi...)Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc3ccccc23)N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1 |c:5,t:23| Show InChI InChI=1S/C32H32ClN5O4/c1-4-42-32(40)30-25(19-41-18-17-38-21(3)36-24-13-7-8-14-26(24)38)35-20(2)28(29(30)22-11-5-6-12-23(22)33)31(39)37-27-15-9-10-16-34-27/h5-16,28-29H,4,17-19H2,1-3H3,(H,34,37,39) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004645
(4-Benzo[b]thiophen-3-yl-6-methyl-2-[4-(2-methyl-im...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1csc2ccccc12)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C36H30N6O3S/c1-4-45-36(44)33-32(26-20-46-29-10-6-5-9-25(26)29)31(35(43)41-30-11-7-8-17-38-30)21(2)39-34(33)23-12-14-24(15-13-23)42-22(3)40-27-19-37-18-16-28(27)42/h5-20,31-32H,4H2,1-3H3,(H,38,41,43) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004646
(4-Benzo[1,3]dioxol-4-yl-6-methyl-2-[4-(2-methyl-im...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1cccc2OCOc12)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C35H30N6O5/c1-4-44-35(43)31-30(24-8-7-9-27-33(24)46-19-45-27)29(34(42)40-28-10-5-6-16-37-28)20(2)38-32(31)22-11-13-23(14-12-22)41-21(3)39-25-18-36-17-15-26(25)41/h5-18,29-30H,4,19H2,1-3H3,(H,37,40,42) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004631
(5-tert-Butylcarbamoyl-4-(2-chloro-phenyl)-6-methyl...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)NC(C)(C)C)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C33H34ClN5O3/c1-7-42-32(41)29-28(23-10-8-9-11-24(23)34)27(31(40)38-33(4,5)6)19(2)36-30(29)21-12-14-22(15-13-21)39-20(3)37-25-18-35-17-16-26(25)39/h8-18,27-28H,7H2,1-6H3,(H,38,40) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004632
(4-(2-Chloro-phenyl)-2-[4-(2-ethyl-imidazo[4,5-c]py...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(CC)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C35H31ClN6O3/c1-4-29-40-26-20-37-19-17-27(26)42(29)23-15-13-22(14-16-23)33-32(35(44)45-5-2)31(24-10-6-7-11-25(24)36)30(21(3)39-33)34(43)41-28-12-8-9-18-38-28/h6-20,30-31H,4-5H2,1-3H3,(H,38,41,43) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50033217
(7,8-Dichloro-2-[4-(2-methyl-imidazo[4,5-c]pyridin-...)Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(Cl)c(Cl)cc2C(=O)NC1 |t:19| Show InChI InChI=1S/C22H15Cl2N5O/c1-12-27-20-10-25-7-6-21(20)29(12)14-4-2-13(3-5-14)19-11-26-22(30)15-8-16(23)17(24)9-18(15)28-19/h2-10H,11H2,1H3,(H,26,30) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets. |
J Med Chem 38: 3514-23 (1995)
BindingDB Entry DOI: 10.7270/Q2PK0GSS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004633
((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C34H29ClN6O3/c1-4-44-34(43)31-30(24-9-5-6-10-25(24)35)29(33(42)40-28-11-7-8-17-37-28)20(2)38-32(31)22-12-14-23(15-13-22)41-21(3)39-26-19-36-18-16-27(26)41/h5-19,29-30H,4H2,1-3H3,(H,37,40,42) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004633
((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C34H29ClN6O3/c1-4-44-34(43)31-30(24-9-5-6-10-25(24)35)29(33(42)40-28-11-7-8-17-37-28)20(2)38-32(31)22-12-14-23(15-13-22)41-21(3)39-26-19-36-18-16-27(26)41/h5-19,29-30H,4H2,1-3H3,(H,37,40,42) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets. |
J Med Chem 38: 3514-23 (1995)
BindingDB Entry DOI: 10.7270/Q2PK0GSS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50004633
((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C34H29ClN6O3/c1-4-44-34(43)31-30(24-9-5-6-10-25(24)35)29(33(42)40-28-11-7-8-17-37-28)20(2)38-32(31)22-12-14-23(15-13-22)41-21(3)39-26-19-36-18-16-27(26)41/h5-19,29-30H,4H2,1-3H3,(H,37,40,42) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50033218
(1-Methyl-4-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl...)Show SMILES CN1c2ccccc2N=C(CC1=O)c1ccc(cc1)-n1c(C)nc2cnccc12 |c:9| Show InChI InChI=1S/C23H19N5O/c1-15-25-20-14-24-12-11-22(20)28(15)17-9-7-16(8-10-17)19-13-23(29)27(2)21-6-4-3-5-18(21)26-19/h3-12,14H,13H2,1-2H3 | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets. |
J Med Chem 38: 3514-23 (1995)
BindingDB Entry DOI: 10.7270/Q2PK0GSS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50004633
((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C34H29ClN6O3/c1-4-44-34(43)31-30(24-9-5-6-10-25(24)35)29(33(42)40-28-11-7-8-17-37-28)20(2)38-32(31)22-12-14-23(15-13-22)41-21(3)39-26-19-36-18-16-27(26)41/h5-19,29-30H,4H2,1-3H3,(H,37,40,42) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50033224
(4-[4-(2-Methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]...)Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2ccccc2NC(=O)C1 |t:19| Show InChI InChI=1S/C22H17N5O/c1-14-24-20-13-23-11-10-21(20)27(14)16-8-6-15(7-9-16)19-12-22(28)26-18-5-3-2-4-17(18)25-19/h2-11,13H,12H2,1H3,(H,26,28) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets. |
J Med Chem 38: 3514-23 (1995)
BindingDB Entry DOI: 10.7270/Q2PK0GSS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004641
(4-(2-Chloro-phenyl)-6-methyl-2-[4-(6-methyl-imidaz...)Show SMILES CCOC(=O)C1=C(NC(C)=C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-c1c(C)nc2sccn12 |c:9,t:5| Show InChI InChI=1S/C33H28ClN5O3S/c1-4-42-32(41)28-27(23-9-5-6-10-24(23)34)26(31(40)38-25-11-7-8-16-35-25)19(2)36-29(28)21-12-14-22(15-13-21)30-20(3)37-33-39(30)17-18-43-33/h5-18,27,36H,4H2,1-3H3,(H,35,38,40) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004625
(5-Carbamoyl-4-(2-chloro-phenyl)-6-methyl-2-[4-(2-m...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(N)=O)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C29H26ClN5O3/c1-4-38-29(37)26-25(20-7-5-6-8-21(20)30)24(28(31)36)16(2)33-27(26)18-9-11-19(12-10-18)35-17(3)34-22-15-32-14-13-23(22)35/h5-15,24-25H,4H2,1-3H3,(H2,31,36) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004648
(4-(2-Chloro-phenyl)-6-methyl-5-(pyridin-2-ylcarbam...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2c(C)nc(C)cc12 |t:5,7| Show InChI InChI=1S/C36H33ClN6O3/c1-6-46-36(45)32-31(26-11-7-8-12-27(26)37)30(35(44)42-29-13-9-10-18-38-29)21(3)40-34(32)24-14-16-25(17-15-24)43-23(5)41-33-22(4)39-20(2)19-28(33)43/h7-19,30-31H,6H2,1-5H3,(H,38,42,44) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286211
(4-(2-Chloro-phenyl)-6-methyl-2-[2-(2-methyl-imidaz...)Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc3ncccc23)N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1 |c:5,t:23| Show InChI InChI=1S/C31H31ClN6O4/c1-4-42-31(40)28-23(18-41-17-16-38-20(3)36-29-24(38)12-9-15-34-29)35-19(2)26(27(28)21-10-5-6-11-22(21)32)30(39)37-25-13-7-8-14-33-25/h5-15,26-27H,4,16-18H2,1-3H3,(H,33,37,39) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286206
((R)-5-tert-Butylcarbamoyl-4-(2-chloro-phenyl)-6-me...)Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc3ccccc23)N=C(C)C([C@H]1c1ccccc1Cl)C(=O)NC(C)(C)C |c:5,t:23| Show InChI InChI=1S/C31H37ClN4O4/c1-7-40-30(38)28-24(18-39-17-16-36-20(3)34-23-14-10-11-15-25(23)36)33-19(2)26(29(37)35-31(4,5)6)27(28)21-12-8-9-13-22(21)32/h8-15,26-27H,7,16-18H2,1-6H3,(H,35,37)/t26?,27-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286204
(4-(2-Chloro-phenyl)-6-methyl-2-[2-(2-methyl-imidaz...)Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc3cnccc23)N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1 |c:5,t:23| Show InChI InChI=1S/C31H31ClN6O4/c1-4-42-31(40)29-24(18-41-16-15-38-20(3)36-23-17-33-14-12-25(23)38)35-19(2)27(28(29)21-9-5-6-10-22(21)32)30(39)37-26-11-7-8-13-34-26/h5-14,17,27-28H,4,15-16,18H2,1-3H3,(H,34,37,39) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286207
(4-(2-Chloro-phenyl)-6-methyl-2-[2-(2-methyl-imidaz...)Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc3cccnc23)N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1 |c:5,t:23| Show InChI InChI=1S/C31H31ClN6O4/c1-4-42-31(40)28-24(18-41-17-16-38-20(3)36-23-12-9-15-34-29(23)38)35-19(2)26(27(28)21-10-5-6-11-22(21)32)30(39)37-25-13-7-8-14-33-25/h5-15,26-27H,4,16-18H2,1-3H3,(H,33,37,39) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004642
(4-(2-Chloro-phenyl)-2-[4-(2,4-dimethyl-thiazol-5-y...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-c1sc(C)nc1C |t:5,7| Show InChI InChI=1S/C32H29ClN4O3S/c1-5-40-32(39)28-27(23-10-6-7-11-24(23)33)26(31(38)37-25-12-8-9-17-34-25)18(2)36-29(28)21-13-15-22(16-14-21)30-19(3)35-20(4)41-30/h6-17,26-27H,5H2,1-4H3,(H,34,37,38) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286201
(4-(2-Chloro-phenyl)-6-methyl-5-(6-methyl-pyridin-2...)Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc(C)c2C)N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1cccc(C)n1 |c:5,t:20| Show InChI InChI=1S/C31H36ClN5O4/c1-7-41-31(39)29-25(17-40-16-15-37-21(5)19(3)34-22(37)6)35-20(4)27(28(29)23-12-8-9-13-24(23)32)30(38)36-26-14-10-11-18(2)33-26/h8-14,27-28H,7,15-17H2,1-6H3,(H,33,36,38) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004636
(4-(2-Chloro-phenyl)-2-[4-(3,5-dimethyl-[1,2,4]tria...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nnc1C |t:5,7| Show InChI InChI=1S/C31H29ClN6O3/c1-5-41-31(40)28-27(23-10-6-7-11-24(23)32)26(30(39)35-25-12-8-9-17-33-25)18(2)34-29(28)21-13-15-22(16-14-21)38-19(3)36-37-20(38)4/h6-17,26-27H,5H2,1-4H3,(H,33,35,39) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004644
(4-(2-Chloro-phenyl)-2-[4-(2,4-dimethyl-imidazol-1-...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1cc(C)nc1C |t:5,7| Show InChI InChI=1S/C32H30ClN5O3/c1-5-41-32(40)29-28(24-10-6-7-11-25(24)33)27(31(39)37-26-12-8-9-17-34-26)20(3)36-30(29)22-13-15-23(16-14-22)38-18-19(2)35-21(38)4/h6-18,27-28H,5H2,1-4H3,(H,34,37,39) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004643
(2-Chloro-6'-methyl-2'-[4-(2-methyl-imidazo[4,5-c]p...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1cccnc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C33H28ClN7O3/c1-4-44-33(43)29-28(23-8-7-16-37-31(23)34)27(32(42)40-26-9-5-6-15-36-26)19(2)38-30(29)21-10-12-22(13-11-21)41-20(3)39-24-18-35-17-14-25(24)41/h5-18,27-28H,4H2,1-3H3,(H,36,40,42) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004628
(4-(2-Chloro-phenyl)-2-methyl-6-[4-(2-methyl-imidaz...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(O)=O)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C29H25ClN4O4/c1-4-38-29(37)26-25(20-7-5-6-8-21(20)30)24(28(35)36)16(2)32-27(26)18-9-11-19(12-10-18)34-17(3)33-22-15-31-14-13-23(22)34/h5-15,24-25H,4H2,1-3H3,(H,35,36) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004639
(6'-Methyl-2'-[4-(2-methyl-imidazo[4,5-c]pyridin-1-...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccn1)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7| Show InChI InChI=1S/C33H29N7O3/c1-4-43-33(42)30-29(24-9-5-7-16-35-24)28(32(41)39-27-10-6-8-17-36-27)20(2)37-31(30)22-11-13-23(14-12-22)40-21(3)38-25-19-34-18-15-26(25)40/h5-19,28-29H,4H2,1-3H3,(H,36,39,41) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004626
(4-(2-Chloro-phenyl)-6-methyl-5-(pyridin-2-ylcarbam...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc(C)c1C |t:5,7| Show InChI InChI=1S/C33H32ClN5O3/c1-6-42-33(41)30-29(25-11-7-8-12-26(25)34)28(32(40)38-27-13-9-10-18-35-27)20(3)37-31(30)23-14-16-24(17-15-23)39-21(4)19(2)36-22(39)5/h7-18,28-29H,6H2,1-5H3,(H,35,38,40) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50033215
(2-[4-(2-Methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]...)Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2ccccc2C(=O)CC1 |t:19| Show InChI InChI=1S/C23H18N4O/c1-15-25-21-14-24-13-12-22(21)27(15)17-8-6-16(7-9-17)19-10-11-23(28)18-4-2-3-5-20(18)26-19/h2-9,12-14H,10-11H2,1H3 | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets. |
J Med Chem 38: 3514-23 (1995)
BindingDB Entry DOI: 10.7270/Q2PK0GSS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286212
((R)-4-(2-Chloro-phenyl)-2-methyl-6-[2-(2,4,5-trime...)Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc(C)c2C)N=C(C)C([C@H]1c1ccccc1Cl)C(=O)OC |c:5,t:20| Show InChI InChI=1S/C26H32ClN3O5/c1-7-35-26(32)24-21(14-34-13-12-30-17(4)15(2)28-18(30)5)29-16(3)22(25(31)33-6)23(24)19-10-8-9-11-20(19)27/h8-11,22-23H,7,12-14H2,1-6H3/t22?,23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286209
(4-(2-Chloro-phenyl)-6-methyl-5-phenylcarbamoyl-2-[...)Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc(C)c2C)N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccc1 |c:5,t:20| Show InChI InChI=1S/C31H35ClN4O4/c1-6-40-31(38)29-26(18-39-17-16-36-21(4)19(2)33-22(36)5)34-20(3)27(28(29)24-14-10-11-15-25(24)32)30(37)35-23-12-8-7-9-13-23/h7-15,27-28H,6,16-18H2,1-5H3,(H,35,37) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286202
((S)-4-(2-Chloro-phenyl)-2-methyl-6-[2-(2,4,5-trime...)Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc(C)c2C)N=C(C)C([C@@H]1c1ccccc1Cl)C(=O)OC |c:5,t:20| Show InChI InChI=1S/C26H32ClN3O5/c1-7-35-26(32)24-21(14-34-13-12-30-17(4)15(2)28-18(30)5)29-16(3)22(25(31)33-6)23(24)19-10-8-9-11-20(19)27/h8-11,22-23H,7,12-14H2,1-6H3/t22?,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004618
(4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-imidaz...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2ccncc12 |t:5,7| Show InChI InChI=1S/C34H29ClN6O3/c1-4-44-34(43)31-30(24-9-5-6-10-25(24)35)29(33(42)40-28-11-7-8-17-37-28)20(2)38-32(31)22-12-14-23(15-13-22)41-21(3)39-26-16-18-36-19-27(26)41/h5-19,29-30H,4H2,1-3H3,(H,37,40,42) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286210
(5-tert-Butylcarbamoyl-4-(2-chloro-phenyl)-6-methyl...)Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc(C)c2C)N=C(C)C(C1c1ccccc1Cl)C(=O)NC(C)(C)C |c:5,t:20| Show InChI InChI=1S/C29H39ClN4O4/c1-9-38-28(36)26-23(16-37-15-14-34-19(4)17(2)31-20(34)5)32-18(3)24(27(35)33-29(6,7)8)25(26)21-12-10-11-13-22(21)30/h10-13,24-25H,9,14-16H2,1-8H3,(H,33,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit |
Bioorg Med Chem Lett 5: 3085-3090 (1995)
Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50004627
(4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-imidaz...)Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1ccnc1C |t:5,7| Show InChI InChI=1S/C31H28ClN5O3/c1-4-40-31(39)28-27(23-9-5-6-10-24(23)32)26(30(38)36-25-11-7-8-16-34-25)19(2)35-29(28)21-12-14-22(15-13-21)37-18-17-33-20(37)3/h5-18,26-27H,4H2,1-3H3,(H,34,36,38) | MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets. |
J Med Chem 35: 3115-29 (1992)
BindingDB Entry DOI: 10.7270/Q28W3DX8 |
More data for this
Ligand-Target Pair | |
Search and Browse
