| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1A adrenergic receptor |
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| Ligand | BDBM50368441 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_32975 (CHEMBL644690) |
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| IC50 | 900±n/a nM |
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| Citation |  Elliott, JM; Selnick, HG; Claremon, DA; Baldwin, JJ; Buhrow, SA; Butcher, JW; Habecker, CN; King, SW; Lynch, JJ; Phillips, BT 4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)- ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-on e (L-691,121). J Med Chem35:3973-6 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1A adrenergic receptor |
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| Name: | Alpha-1A adrenergic receptor |
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| Synonyms: | ADA1A_BOVIN | ADRA1A | ADRA1C | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha-1C adrenergic receptor | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51492.08 |
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| Organism: | CALF |
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| Description: | adrenergic Alpha1 0 CALF |
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| Residue: | 466 |
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| Sequence: | MVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
AQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTL
HAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACT
TARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV
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| BDBM50368441 |
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| n/a |
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| Name | BDBM50368441 |
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| Synonyms: | CHEMBL1203302 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25N3O6S |
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| Mol. Mass. | 459.515 |
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| SMILES | CS(=O)(=O)Nc1ccc2OC3(CCN(CCc4ccc(cc4)[N+]([O-])=O)CC3)CC(=O)c2c1 |
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| Structure | 
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