| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50005916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_162185 |
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| IC50 | 900±n/a nM |
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| Citation |  Sircar, JC; Kostlan, CR; Gilbertsen, RB; Bennett, MK; Dong, MK; Cetenko, WJ Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-o J Med Chem35:1605-9 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50005916 |
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| n/a |
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| Name | BDBM50005916 |
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| Synonyms: | 2,6-diamino-7-(thien-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride | CHEMBL554876 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H11N5OS |
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| Mol. Mass. | 261.303 |
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| SMILES | Nc1[nH]c2c(nc(N)[nH]c2=O)c1Cc1ccsc1 |
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| Structure | 
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