| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM50045033 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_141645 (CHEMBL749546) |
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| IC50 | 824±n/a nM |
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| Citation |  Kucharczyk, N; Thurieau, C; Paladino, J; Morris, AD; Bonnet, J; Canet, E; Krause, JE; Regoli, D; Couture, R; Fauchère, JL Tetrapeptide tachykinin antagonists: synthesis and modulation of the physicochemical and pharmacological properties of a new series of partially cyclic analogs. J Med Chem36:1654-61 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK-2 receptor | NK-2R | NK2R_RAT | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | SKR | Substance-K receptor | Tac2r | Tachykinin receptor 2 | Tacr2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43868.63 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Neurokinin NK2 TACR2 Murine::P16610 |
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| Residue: | 390 |
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| Sequence: | MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILA
HERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVALALASPQCFYSTITVDEGATK
CVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRAVPRHQAHGANLR
HLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIYYHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNRCHTKETLFMT
GDMTHSEATNGQVGSPQDGEPAGPICKAQA
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| BDBM50045033 |
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| n/a |
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| Name | BDBM50045033 |
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| Synonyms: | 1N-[1-[1-benzyl(methyl)carbamoyl-2-phenyl-(1S)-ethylcarbamoyl]-2-(1-formyl-1H-3-indolyl)-(1R)-ethyl]-3-hydroxy-2-methylcarboxamidobutanamide | CHEMBL297776 | FR-113680 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H39N5O6 |
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| Mol. Mass. | 625.7141 |
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| SMILES | CC(O)[C@H](NC(C)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 |
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| Structure | 
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