Reaction Details |
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Target | Platelet-activating factor receptor |
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Ligand | BDBM50033244 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_155148 (CHEMBL760189) |
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IC50 | 55±n/a nM |
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Citation | Fray, MJ; Bull, DJ; Cooper, K; Parry, MJ; Stefaniak, MH Novel antagonists of platelet-activating factor. 2. Synthesis and structure-activity relationships of potent and long-acting heterofused [1,5]benzodiazepine and [1,4]diazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine. J Med Chem38:3524-35 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Platelet-activating factor receptor |
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Name: | Platelet-activating factor receptor |
Synonyms: | PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor |
Type: | Protein |
Mol. Mass.: | 39005.63 |
Organism: | Cavia porcellus |
Description: | n/a |
Residue: | 342 |
Sequence: | MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLT
VADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVK
YPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKG
SKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAV
FVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
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BDBM50033244 |
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n/a |
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Name | BDBM50033244 |
Synonyms: | 8,9-Dimethyl-5-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-2,4-dihydro-2,3,6,10b-tetraaza-benzo[e]azulen-1-one | CHEMBL332542 |
Type | Small organic molecule |
Emp. Form. | C25H21N7O |
Mol. Mass. | 435.4805 |
SMILES | Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(C)c(C)cc2-n2c(C1)n[nH]c2=O |t:19| |
Structure |
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