Reaction Details |
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Target | Platelet-activating factor receptor |
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Ligand | BDBM50033241 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_155148 (CHEMBL760189) |
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IC50 | 3.5±n/a nM |
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Citation | Fray, MJ; Bull, DJ; Cooper, K; Parry, MJ; Stefaniak, MH Novel antagonists of platelet-activating factor. 2. Synthesis and structure-activity relationships of potent and long-acting heterofused [1,5]benzodiazepine and [1,4]diazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine. J Med Chem38:3524-35 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Platelet-activating factor receptor |
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Name: | Platelet-activating factor receptor |
Synonyms: | PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor |
Type: | Protein |
Mol. Mass.: | 39005.63 |
Organism: | Cavia porcellus |
Description: | n/a |
Residue: | 342 |
Sequence: | MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLT
VADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVK
YPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKG
SKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAV
FVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
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BDBM50033241 |
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n/a |
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Name | BDBM50033241 |
Synonyms: | 3-Isopropyl-1,8-dimethyl-5-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-6,8-dihydro-1H-pyrazolo[3,4-b][1,4]diazepin-7-one | CHEMBL118793 |
Type | Small organic molecule |
Emp. Form. | C24H25N7O |
Mol. Mass. | 427.5016 |
SMILES | CC(C)c1nn(C)c2N(C)C(=O)CC(=Nc12)c1ccc(cc1)-n1c(C)nc2cnccc12 |c:13| |
Structure |
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