Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50033826 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_205570 (CHEMBL807903) |
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IC50 | 4333±n/a nM |
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Citation | Lewis, RT; Macleod, AM; Merchant, KJ; Kelleher, F; Sanderson, I; Herbert, RH; Cascieri, MA; Sadowski, S; Ball, RG; Hoogsteen, K Tryptophan-derived NK1 antagonists: conformationally constrained heterocyclic bioisosteres of the ester linkage. J Med Chem38:923-33 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46254.43 |
Organism: | Homo sapiens (Human) |
Description: | P25103 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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BDBM50033826 |
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n/a |
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Name | BDBM50033826 |
Synonyms: | 1-(3,5-Bis-trifluoromethyl-benzyl)-3-(1H-indol-3-ylmethyl)-piperazine-2,5-dione | CHEMBL172308 |
Type | Small organic molecule |
Emp. Form. | C22H17F6N3O2 |
Mol. Mass. | 469.3797 |
SMILES | FC(F)(F)c1cc(CN2CC(=O)NC(Cc3c[nH]c4ccccc34)C2=O)cc(c1)C(F)(F)F |
Structure |
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