| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
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| Ligand | BDBM50053410 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_4170 (CHEMBL619237) |
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| IC50 | >100000±n/a nM |
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| Citation |  Boehm, JC; Smietana, JM; Sorenson, ME; Garigipati, RS; Gallagher, TF; Sheldrake, PL; Bradbeer, J; Badger, AM; Laydon, JT; Lee, JC; Hillegass, LM; Griswold, DE; Breton, JJ; Chabot-Fletcher, MC; Adams, JL 1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency. J Med Chem39:3929-37 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid 5-lipoxygenase |
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| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
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| Synonyms: | Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78082.31 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1432947 |
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| Residue: | 673 |
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| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
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| BDBM50053410 |
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| n/a |
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| Name | BDBM50053410 |
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| Synonyms: | 4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole | 4-[5-(4-Fluoro-phenyl)-3H-imidazol-4-yl]-pyridine | CHEMBL63135 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10FN3 |
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| Mol. Mass. | 239.2477 |
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| SMILES | Fc1ccc(cc1)-c1[nH]cnc1-c1ccncc1 |
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| Structure | 
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