| Reaction Details |
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 | Report a problem with these data |
| Target | DNA topoisomerase 1 |
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| Ligand | BDBM50055653 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_208415 (CHEMBL821422) |
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| IC50 | 4597±n/a nM |
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| Citation |  Zhao, R; al-Said, NH; Sternbach, DL; Lown, JW Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro. J Med Chem40:216-25 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA topoisomerase 1 |
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| Name: | DNA topoisomerase 1 |
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| Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 90771.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11387 |
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| Residue: | 765 |
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| Sequence: | MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
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| BDBM50055653 |
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| n/a |
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| Name | BDBM50055653 |
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| Synonyms: | 10-[[[1-(Methoxymethyl)-2-[[3-(dimethylamino)propyl]carbamoyl]pyrrol-4-yl]carbamoyl]methoxy]-2(R,S)-camptothecin | CHEMBL312690 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H38N6O9 |
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| Mol. Mass. | 674.7003 |
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| SMILES | CCC1(O)C(=O)OCc2c1cc1-c3nc4ccc(OCC(=O)ONc5cc(C(=O)NCCCN(C)C)n(COC)c5)cc4cc3Cn1c2=O |
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| Structure | 
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