Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50008923 ((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055662 ((4-Ethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055647 (10-[2-[1-(Methoxymethyl)-4-[1-(methoxymethyl)-4-[1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055646 (4-Butyrylamino-1-methoxymethyl-1H-imidazole-2-carb...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055656 (10-[2-[1-(Methoxymethyl)-4-[1-(methoxymethyl)-4-bu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055661 (4-(4-Dimethylamino-butyrylamino)-1-methoxymethyl-1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055659 (2N-(3,3-aminoiminopropyl)-4-[4-(4-formamido-1-meth...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055649 (10-[[[1-(Methoxymethyl)-2-[[1-(methoxymethyl)-2-[[...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055652 (10-[[[1-(Methoxymethyl)-2-[[1-(methoxymethyl)-2-ca...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055653 (10-[[[1-(Methoxymethyl)-2-[[3-(dimethylamino)propy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055651 (10-[2-[1-(Methoxymethyl)-4-[1-(methoxymethyl)-4-[4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055650 (10-[[[1-(Methoxymethyl)-2-carbethoxypyrrol-4-yl]ca...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055663 (10-[[[1-(Methoxymethyl)-2-[[1-(methoxymethyl)-2-[[...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055648 (10-[2-[1-(Methoxymethyl)-4-[1-(methoxymethyl)-4-bu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50055660 (1-amino-3-(4-(4-(2-(amino(iminio)methylamino)aceta...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibit supercoil relaxation property of topoisomerase I. | J Med Chem 40: 216-25 (1997) Article DOI: 10.1021/jm9605804 BindingDB Entry DOI: 10.7270/Q2F47PS8 | |||||||||||
More data for this Ligand-Target Pair |