Reaction Details | |||
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Target | Tissue-type plasminogen activator | ||
Ligand | BDBM50060705 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_208240 (CHEMBL872720) | ||
Ki | >1000000±n/a nM | ||
Citation | Tucker, TJ; Lumma, WC; Lewis, SD; Gardell, SJ; Lucas, BJ; Sisko, JT; Lynch, JJ; Lyle, EA; Baskin, EP; Woltmann, RF; Appleby, SD; Chen, IW; Dancheck, KB; Naylor-Olsen, AM; Krueger, JA; Cooper, CM; Vacca, JP Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position. J Med Chem40:3687-93 (1997) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Tissue-type plasminogen activator | |||
Name: | Tissue-type plasminogen activator | ||
Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator | ||
Type: | Enzyme | ||
Mol. Mass.: | 62931.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 562 | ||
Sequence: |
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BDBM50060705 | |||
n/a | |||
Name | BDBM50060705 | ||
Synonyms: | (S)-1-(3,3-Diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide; TFA | CHEMBL122894 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H35N3O2 | ||
Mol. Mass. | 433.5857 | ||
SMILES | NC1CCC(CNC(=O)[C@@H]2CCCN2C(=O)CC(c2ccccc2)c2ccccc2)CC1 |wU:9.8,(18.93,-14,;17.97,-12.81,;16.65,-12.04,;17.27,-10.34,;16.88,-9.19,;15.48,-8.55,;15.31,-7.01,;13.92,-6.4,;12.67,-7.29,;13.76,-4.86,;14.9,-3.83,;14.28,-2.42,;12.75,-2.58,;12.43,-4.09,;11.02,-4.7,;10.86,-6.24,;9.79,-3.8,;9.76,-2.26,;8.44,-1.49,;7.09,-2.26,;5.78,-1.49,;5.78,.05,;7.09,.82,;8.44,.05,;11.1,-1.49,;12.43,-2.26,;13.76,-1.49,;13.76,.05,;12.42,.82,;11.08,.05,;18.2,-9.96,;17.56,-11.56,)| | ||
Structure |