Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50061803 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_201737 (CHEMBL803933) |
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IC50 | 79±n/a nM |
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Citation | Hu, LY; Guo, J; Magar, SS; Fischer, JB; Burke-Howie, KJ; Durant, GJ Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers. J Med Chem40:4281-9 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50061803 |
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n/a |
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Name | BDBM50061803 |
Synonyms: | CHEMBL540831 | N'-(3-Ethyl-2-fluoro-5-trifluoromethyl-phenyl)-N-(3-ethyl-phenyl)-N-methyl-guanidine; hydrochloride |
Type | Small organic molecule |
Emp. Form. | C19H21F4N3 |
Mol. Mass. | 367.3838 |
SMILES | CCc1cccc(c1)N(C)C(N)=Nc1cc(cc(CC)c1F)C(F)(F)F |w:12.13| |
Structure |
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