Reaction Details |
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Target | Integrase |
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Ligand | BDBM50073633 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_88621 (CHEMBL701725) |
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IC50 | >10000±n/a nM |
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Citation | King, PJ; Ma, G; Miao, W; Jia, Q; McDougall, BR; Reinecke, MG; Cornell, C; Kuan, J; Kim, TR; Robinson, WE Structure-activity relationships: analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication. J Med Chem42:497-509 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Integrase |
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Name: | Integrase |
Synonyms: | Human immunodeficiency virus type 1 integrase |
Type: | PROTEIN |
Mol. Mass.: | 32231.48 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_90865 |
Residue: | 288 |
Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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BDBM50073633 |
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n/a |
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Name | BDBM50073633 |
Synonyms: | (E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid 2-[(E)-3-(3,4-dihydroxy-phenyl)-acryloyloxy]-cyclohexyl ester | CHEMBL348709 |
Type | Small organic molecule |
Emp. Form. | C24H24O8 |
Mol. Mass. | 440.4426 |
SMILES | Oc1ccc(\C=C\C(=O)OC2CCCCC2OC(=O)\C=C\c2ccc(O)c(O)c2)cc1O |
Structure |
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