| Reaction Details |
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 | Report a problem with these data |
| Target | Glutathione reductase, mitochondrial |
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| Ligand | BDBM50091149 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_72595 (CHEMBL681183) |
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| Ki | 2200000±n/a nM |
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| Citation |  Khan, MO; Austin, SE; Chan, C; Yin, H; Marks, D; Vaghjiani, SN; Kendrick, H; Yardley, V; Croft, SL; Douglas, KT Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines. J Med Chem43:3148-56 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutathione reductase, mitochondrial |
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| Name: | Glutathione reductase, mitochondrial |
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| Synonyms: | GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56271.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00390 |
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| Residue: | 522 |
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| Sequence: | MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
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| BDBM50091149 |
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| n/a |
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| Name | BDBM50091149 |
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| Synonyms: | (4-Chloro-benzyl)-[3-(2-chloro-phenothiazin-10-yl)-propyl]-dimethyl-ammonium (OFK002) | CHEMBL105769 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25Cl2N2S |
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| Mol. Mass. | 444.439 |
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| SMILES | C[N+](C)(CCCN1c2ccccc2Sc2ccc(Cl)cc12)Cc1ccc(Cl)cc1 |
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| Structure | 
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