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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Prostaglandin G/H synthase 2 | ||
| Ligand | BDBM50084342 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_159907 (CHEMBL768956) | ||
| IC50 | 6500±n/a nM | ||
| Citation |  Puig, C; Crespo, MI; Godessart, N; Feixas, J; Ibarzo, J; Jiménez, JM; Soca, L; Cardelús, I; Heredia, A; Miralpeix, M; Puig, J; Beleta, J; Huerta, JM; López, M; Segarra, V; Ryder, H; Palacios, JM Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors. J Med Chem43:214-23 (2000) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Prostaglandin G/H synthase 2 | |||
| Name: | Prostaglandin G/H synthase 2 | ||
| Synonyms: | COX2 | Cyclooxygenase | Cyclooxygenase 2 (COX-2) | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2 AA) | Cyclooxygenase-2 (COX-2 AEA) | Cyclooxygenase-2 (COX-2) | PGH synthase 2 | PGH2_HUMAN | PGHS-2 | PHS II | PTGS2 | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 69003.89 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Recombinant Cox-2 provided by Cayman (Cayman Chemical Co.,Ann Arbor, MI). | ||
| Residue: | 604 | ||
| Sequence: |
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| BDBM50084342 | |||
| n/a | |||
| Name | BDBM50084342 | ||
| Synonyms: | 4-[3-(2-Chloro-phenyl)-2-oxo-2,3-dihydro-oxazol-4-yl]-benzenesulfonamide | CHEMBL71010 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C15H11ClN2O4S | ||
| Mol. Mass. | 350.777 | ||
| SMILES | NS(=O)(=O)c1ccc(cc1)-c1coc(=O)n1-c1ccccc1Cl |(4.41,-9.17,;5.68,-10.06,;6.94,-10.95,;4.78,-11.33,;6.56,-8.8,;8.12,-8.92,;8.99,-7.64,;8.31,-6.26,;6.77,-6.14,;5.9,-7.4,;9.19,-5,;10.72,-5.02,;11.21,-3.6,;9.99,-2.67,;10.02,-1.13,;8.75,-3.53,;7.66,-2.43,;8.07,-.96,;6.98,.13,;5.49,-.28,;5.09,-1.73,;6.18,-2.83,;5.77,-4.32,)| | ||
| Structure | 
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