Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50084878 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_50978 (CHEMBL663521) | ||
Ki | 0.4±n/a nM | ||
Citation | He, L; Gilligan, PJ; Zaczek, R; Fitzgerald, LW; McElroy, J; Shen, HS; Saye, JA; Kalin, NH; Shelton, S; Christ, D; Trainor, G; Hartig, P 4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2, 4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: a potent, orally bioavailable CRF(1) receptor antagonist. J Med Chem43:449-56 (2000) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
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BDBM50084878 | |||
n/a | |||
Name | BDBM50084878 | ||
Synonyms: | Butyl-[8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]-ethyl-amine | CHEMBL341820 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H23Cl2N5 | ||
Mol. Mass. | 392.325 | ||
SMILES | CCCCN(CC)c1nc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl |(6.56,7.35,;6.07,5.89,;4.59,5.55,;4.12,4.1,;2.61,3.75,;1.57,4.9,;2.03,6.37,;2.13,2.3,;.64,1.96,;.17,.5,;-1.34,.16,;1.22,-.62,;2.71,-.3,;3.96,-1.2,;5.2,-.3,;6.65,-.77,;4.72,1.18,;3.18,1.16,;3.96,-2.74,;2.64,-3.51,;2.64,-5.05,;3.96,-5.82,;3.96,-7.36,;5.3,-5.05,;5.3,-3.51,;6.62,-2.73,)| | ||
Structure |