Reaction Details |
| Report a problem with these data |
Target | Endothelin-converting enzyme 1 |
---|
Ligand | BDBM50084894 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_225950 (CHEMBL843957) |
---|
IC50 | 110±n/a nM |
---|
Citation | De Lombaert, S; Blanchard, L; Stamford, LB; Tan, J; Wallace, EM; Satoh, Y; Fitt, J; Hoyer, D; Simonsbergen, D; Moliterni, J; Marcopoulos, N; Savage, P; Chou, M; Trapani, AJ; Jeng, AY Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action. J Med Chem43:488-504 (2000) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Endothelin-converting enzyme 1 |
---|
Name: | Endothelin-converting enzyme 1 |
Synonyms: | ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1) |
Type: | Enzyme |
Mol. Mass.: | 87155.11 |
Organism: | Homo sapiens (Human) |
Description: | P42892 |
Residue: | 770 |
Sequence: | MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
|
|
|
BDBM50084894 |
---|
n/a |
---|
Name | BDBM50084894 |
Synonyms: | 3-Dibenzofuran-3-yl-2-[3-(2,3-dimethoxy-phenyl)-1-phosphono-propylamino]-propionic acid | CHEMBL423751 |
Type | Small organic molecule |
Emp. Form. | C26H28NO8P |
Mol. Mass. | 513.4762 |
SMILES | COc1cccc(CCC(N[C@@H](Cc2ccc3c(c2)oc2ccccc32)C(O)=O)P(O)(O)=O)c1OC |
Structure |
|