Reaction Details |
| Report a problem with these data |
Target | Leukotriene A-4 hydrolase |
---|
Ligand | BDBM50085271 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_96941 (CHEMBL879999) |
---|
IC50 | 9700±n/a nM |
---|
Citation | Penning, TD; Chandrakumar, NS; Chen, BB; Chen, HY; Desai, BN; Djuric, SW; Docter, SH; Gasiecki, AF; Haack, RA; Miyashiro, JM; Russell, MA; Yu, SS; Corley, DG; Durley, RC; Kilpatrick, BF; Parnas, BL; Askonas, LJ; Gierse, JK; Harding, EI; Highkin, MK; Kachur, JF; Kim, SH; Krivi, GG; Villani-Price, D; Pyla, EY; Smith, WG Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase. J Med Chem43:721-35 (2000) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Leukotriene A-4 hydrolase |
---|
Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
Type: | Hydrolase; metalloprotease |
Mol. Mass.: | 69280.41 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant LTA4H. |
Residue: | 611 |
Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
|
|
|
BDBM50085271 |
---|
n/a |
---|
Name | BDBM50085271 |
Synonyms: | 1-[2-(4-Benzyl-benzenesulfinyl)-ethyl]-pyrrolidine | CHEMBL354015 |
Type | Small organic molecule |
Emp. Form. | C19H23NOS |
Mol. Mass. | 313.457 |
SMILES | O=S(CCN1CCCC1)c1ccc(Cc2ccccc2)cc1 |
Structure |
|