| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H3 receptor |
|---|
| Ligand | BDBM50118161 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_83653 (CHEMBL694882) |
|---|
| Ki | 77±n/a nM |
|---|
| Citation |  Sasse, A; Ligneau, X; Rouleau, A; Elz, S; Ganellin, CR; Arrang, JM; Schwartz, JC; Schunack, W; Stark, H Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties. J Med Chem45:4000-10 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H3 receptor |
|---|
| Name: | Histamine H3 receptor |
|---|
| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 48691.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
|---|
| Residue: | 445 |
|---|
| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
|
|
|
|---|
| BDBM50118161 |
|---|
| n/a |
|---|
| Name | BDBM50118161 |
|---|
| Synonyms: | (1-tert-Butyl-2,2-dimethyl-propyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester;C2H2O4 | CHEMBL128773 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H29N3O2 |
|---|
| Mol. Mass. | 295.4204 |
|---|
| SMILES | CC(C)(C)C(NC(=O)OCCCc1cnc[nH]1)C(C)(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
