| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H1 receptor |
|---|
| Ligand | BDBM50118161 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_84094 (CHEMBL695160) |
|---|
| Kd | 12589.25±n/a nM |
|---|
| Citation |  Sasse, A; Ligneau, X; Rouleau, A; Elz, S; Ganellin, CR; Arrang, JM; Schwartz, JC; Schunack, W; Stark, H Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties. J Med Chem45:4000-10 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H1 receptor |
|---|
| Name: | Histamine H1 receptor |
|---|
| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 55641.53 |
|---|
| Organism: | Cavia porcellus (domestic guinea pig) |
|---|
| Description: | Guinea pig cerebellum was used in binding assay. |
|---|
| Residue: | 488 |
|---|
| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
|
|
|
|---|
| BDBM50118161 |
|---|
| n/a |
|---|
| Name | BDBM50118161 |
|---|
| Synonyms: | (1-tert-Butyl-2,2-dimethyl-propyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester;C2H2O4 | CHEMBL128773 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H29N3O2 |
|---|
| Mol. Mass. | 295.4204 |
|---|
| SMILES | CC(C)(C)C(NC(=O)OCCCc1cnc[nH]1)C(C)(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
