| Reaction Details |
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 | Report a problem with these data |
| Target | D(2) dopamine receptor |
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| Ligand | BDBM50056443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_59901 (CHEMBL883275) |
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| EC50 | 165±n/a nM |
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| Citation |  Cowart, M; Latshaw, SP; Bhatia, P; Daanen, JF; Rohde, J; Nelson, SL; Patel, M; Kolasa, T; Nakane, M; Uchic, ME; Miller, LN; Terranova, MA; Chang, R; Donnelly-Roberts, DL; Namovic, MT; Hollingsworth, PR; Martino, BR; Lynch, JJ; Sullivan, JP; Hsieh, GC; Moreland, RB; Brioni, JD; Stewart, AO Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. J Med Chem47:3853-64 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(2) dopamine receptor |
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| Name: | D(2) dopamine receptor |
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| Synonyms: | D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2 |
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| Type: | Cell-surface receptors |
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| Mol. Mass.: | 50647.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14416 |
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| Residue: | 443 |
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| Sequence: | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC
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| BDBM50056443 |
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| n/a |
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| Name | BDBM50056443 |
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| Synonyms: | (R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-ij]quinolin-2-one | CHEMBL419792 | PNU-95666E |
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| Type | Small organic molecule |
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| Emp. Form. | C11H13N3O |
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| Mol. Mass. | 203.2404 |
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| SMILES | CN[C@@H]1Cc2cccc3[nH]c(=O)n(C1)c23 |
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| Structure | 
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